The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry

Influenza A virus (IAV) coopts numerous host factors to complete its replication cycle. Here, we identify free fatty acid receptor 2 (FFAR2) as a cofactor for IAV entry into host cells. We found that downregulation of FFAR2 or Ffar2 expression significantly reduced the replication of IAV in A549 or...

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Detalles Bibliográficos
Autores principales: Wang, Guangwen, Jiang, Li, Wang, Jinliang, Zhang, Jie, Kong, Fandi, Li, Qibing, Yan, Ya, Huang, Shanyu, Zhao, Yuhui, Liang, Libin, Li, Junping, Sun, Nan, Hu, Yuzhen, Shi, Wenjun, Deng, Guohua, Chen, Pucheng, Liu, Liling, Zeng, Xianying, Tian, Guobin, Bu, Zhigao, Chen, Hualan, Li, Chengjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955252/
https://www.ncbi.nlm.nih.gov/pubmed/31694949
http://dx.doi.org/10.1128/JVI.01707-19

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