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Optimization of the Codon Pair Usage of Human Respiratory Syncytial Virus Paradoxically Resulted in Reduced Viral Replication In Vivo and Reduced Immunogenicity

We subjected various open reading frames (ORFs) in the genome of respiratory syncytial virus (RSV) to codon pair optimization (CPO) by increasing the content of codon pairs that are overrepresented in the human genome without changing overall codon usage and amino acid sequences. CPO has the potenti...

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Detalles Bibliográficos
Autores principales:	Le Nouën, Cyril, Luongo, Cindy L., Yang, Lijuan, Mueller, Steffen, Wimmer, Eckard, DiNapoli, Joshua M., Collins, Peter L., Buchholz, Ursula J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955273/ https://www.ncbi.nlm.nih.gov/pubmed/31666376 http://dx.doi.org/10.1128/JVI.01296-19

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