Cargando…

Amino Acid Mutations A286V and T437M in the Nucleoprotein Attenuate H7N9 Viruses in Mice

The low-pathogenic H7N9 influenza viruses that emerged in 2013 acquired an insertion of four amino acids in their hemagglutinin cleavage site and thereby became highly pathogenic to chickens in 2017. Previous studies indicated that these highly pathogenic H7N9 viruses are virulent in chickens but ha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Shujie, Zhang, Bo, Shi, Jianzhong, Yin, Xin, Wang, Guangwen, Cui, Pengfei, Liu, Liling, Deng, Guohua, Jiang, Yongping, Li, Chengjun, Chen, Hualan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955278/ https://www.ncbi.nlm.nih.gov/pubmed/31666373 http://dx.doi.org/10.1128/JVI.01530-19

Ejemplares similares

Glycine at Position 622 in PB1 Contributes to the Virulence of H5N1 Avian Influenza Virus in Mice
por: Feng, Xiaoxiao, et al.
Publicado: (2016)

A Single-Amino-Acid Substitution at Position 225 in Hemagglutinin Alters the Transmissibility of Eurasian Avian-Like H1N1 Swine Influenza Virus in Guinea Pigs
por: Wang, Zeng, et al.
Publicado: (2017)

Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies
por: Fenwick, Craig, et al.
Publicado: (2021)

Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response
por: Zhao, Dongming, et al.
Publicado: (2017)

Identification of Amino Acids within Nonstructural Proteins 10 and 14 of the Avian Coronavirus Infectious Bronchitis Virus That Result in Attenuation In Vivo and In Ovo
por: Keep, Sarah, et al.
Publicado: (2022)

A Single Amino Acid Substitution in the Novel H7N9 Influenza A Virus NS1 Protein Increases CPSF30 Binding and Virulence
por: Ayllon, Juan, et al.
Publicado: (2014)

Combinational Deletions of MGF360-9L and MGF505-7R Attenuated Highly Virulent African Swine Fever Virus and Conferred Protection against Homologous Challenge
por: Ding, Mingyang, et al.
Publicado: (2022)

Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus
por: Deng, Xufang, et al.
Publicado: (2020)

A Single Amino Acid in the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses
por: Bae, Joon-Yong, et al.
Publicado: (2018)

MALT1 Controls Attenuated Rabies Virus by Inducing Early Inflammation and T Cell Activation in the Brain
por: Kip, E., et al.
Publicado: (2018)

A Single Amino Acid at Position 431 of the PB2 Protein Determines the Virulence of H1N1 Swine Influenza Viruses in Mice
por: Xu, Chengzhi, et al.
Publicado: (2020)

Acute-Phase CD8 T Cell Responses That Select for Escape Variants Are Needed to Control Live Attenuated Simian Immunodeficiency Virus
por: Harris, Max, et al.
Publicado: (2013)

Epitope-Containing Short Peptides Capture Distinct IgG Serodynamics That Enable Differentiating Infected from Vaccinated Animals for Live-Attenuated Vaccines
por: Xue, Qinghong, et al.
Publicado: (2020)

The N-Terminal Region of Middle East Respiratory Syndrome Coronavirus Accessory Protein 8b Is Essential for Enhanced Virulence of an Attenuated Murine Coronavirus
por: Li, Yuming, et al.
Publicado: (2022)

The Unique Glycosylation at Position 986 on the E2 Glycoprotein of Classical Swine Fever Virus Is Responsible for Viral Attenuation and Protection against Lethal Challenge
por: Li, Yongfeng, et al.
Publicado: (2022)

Contribution of Segment 3 to the Acquisition of Virulence in Contemporary H9N2 Avian Influenza Viruses
por: Clements, Anabel L., et al.
Publicado: (2020)

Deletion of both the Tyrosine-Based Endocytosis Signal and the Endoplasmic Reticulum Retrieval Signal in the Cytoplasmic Tail of Spike Protein Attenuates Porcine Epidemic Diarrhea Virus in Pigs
por: Hou, Yixuan, et al.
Publicado: (2019)

CRISPR/Cas9-Constructed Pseudorabies Virus Mutants Reveal the Importance of UL13 in Alphaherpesvirus Escape from Genome Silencing
por: Van Cleemput, Jolien, et al.
Publicado: (2021)

Genetic Compatibility of Reassortants between Avian H5N1 and H9N2 Influenza Viruses with Higher Pathogenicity in Mammals
por: Arai, Yasuha, et al.
Publicado: (2019)

Immune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain Fitness In Vivo and Display Enhanced Zoonotic Characteristics
por: Peacock, Thomas P., et al.
Publicado: (2017)

Combinational Deletions of MGF110-9L and MGF505-7R Genes from the African Swine Fever Virus Inhibit TBK1 Degradation by an Autophagy Activator PIK3C2B To Promote Type I Interferon Production
por: Zhu, Guoqiang, et al.
Publicado: (2023)

Coronavirus Endoribonuclease and Deubiquitinating Interferon Antagonists Differentially Modulate the Host Response during Replication in Macrophages
por: Volk, Aaron, et al.
Publicado: (2020)

Coronavirus Endoribonuclease Activity in Porcine Epidemic Diarrhea Virus Suppresses Type I and Type III Interferon Responses
por: Deng, Xufang, et al.
Publicado: (2019)

Activation of AIM2 by hepatitis B virus results in antiviral immunity that suppresses hepatitis C virus during coinfection
por: Li, Yongqi, et al.
Publicado: (2023)

SARS-CoV-2 Rapidly Adapts in Aged BALB/c Mice and Induces Typical Pneumonia
por: Zhang, Yufei, et al.
Publicado: (2021)

Impact of HLA Selection Pressure on HIV Fitness at a Population Level in Mexico and Barbados
por: Juarez-Molina, Claudia I., et al.
Publicado: (2014)

Virus and Host Factors Affecting the Clinical Outcome of Bluetongue Virus Infection
por: Caporale, Marco, et al.
Publicado: (2014)

High Production Rates Sustain In Vivo Levels of PD-1(high) Simian Immunodeficiency Virus-Specific CD8 T Cells in the Face of Rapid Clearance
por: Petrovas, Constantinos, et al.
Publicado: (2013)

Regulatory T Cells Prevent Th2 Immune Responses and Pulmonary Eosinophilia during Respiratory Syncytial Virus Infection in Mice
por: Durant, Lydia R., et al.
Publicado: (2013)

Glycoprotein B Cleavage Is Important for Murid Herpesvirus 4 To Infect Myeloid Cells
por: Glauser, Daniel L., et al.
Publicado: (2013)

Herpes Simplex Virus 1 Targets the Murine Olfactory Neuroepithelium for Host Entry
por: Shivkumar, Maitreyi, et al.
Publicado: (2013)

Immunosuppression Facilitates the Reactivation of Latent Papillomavirus Infections
por: Maglennon, G. A., et al.
Publicado: (2014)

Delayed Sequelae of Neonatal Respiratory Syncytial Virus Infection Are Dependent on Cells of the Innate Immune System
por: Harker, James A., et al.
Publicado: (2014)

Vaccinia Virus Inhibits NF-κB-Dependent Gene Expression Downstream of p65 Translocation
por: Sumner, Rebecca P., et al.
Publicado: (2014)

Respiratory Syncytial Virus Infection, TLR3 Ligands, and Proinflammatory Cytokines Induce CD161 Ligand LLT1 Expression on the Respiratory Epithelium
por: Satkunanathan, Stifani, et al.
Publicado: (2014)

BAFF Receptor Deficiency Limits Gammaherpesvirus Infection
por: Frederico, Bruno, et al.
Publicado: (2014)

Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1
por: O'Connor, Geraldine M., et al.
Publicado: (2015)

Multiple Genome Segments Determine Virulence of Bluetongue Virus Serotype 8
por: Janowicz, Anna, et al.
Publicado: (2015)

Tick Saliva Enhances Powassan Virus Transmission to the Host, Influencing Its Dissemination and the Course of Disease
por: Hermance, Meghan E., et al.
Publicado: (2015)

Expanding Regulatory T Cells Alleviates Chikungunya Virus-Induced Pathology in Mice
por: Lee, Wendy W. L., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_oir7dbnn8h3lm3j10br9fhdoou