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Enhanced expression of β cell Ca(V)3.1 channels impairs insulin release and glucose homeostasis
Voltage-gated calcium 3.1 (Ca(V)3.1) channels are absent in healthy mouse β cells and mediate minor T-type Ca(2+) currents in healthy rat and human β cells but become evident under diabetic conditions. Whether more active Ca(V)3.1 channels affect insulin secretion and glucose homeostasis remains eni...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955371/ https://www.ncbi.nlm.nih.gov/pubmed/31871187 http://dx.doi.org/10.1073/pnas.1908691117 |