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Enhanced expression of β cell Ca(V)3.1 channels impairs insulin release and glucose homeostasis

Voltage-gated calcium 3.1 (Ca(V)3.1) channels are absent in healthy mouse β cells and mediate minor T-type Ca(2+) currents in healthy rat and human β cells but become evident under diabetic conditions. Whether more active Ca(V)3.1 channels affect insulin secretion and glucose homeostasis remains eni...

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Detalles Bibliográficos
Autores principales:	Yu, Jia, Shi, Yue, Zhao, Kaixuan, Yang, Guang, Yu, Lina, Li, Yuxin, Andersson, Eva-Marie, Ämmälä, Carina, Yang, Shao-Nian, Berggren, Per-Olof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955371/ https://www.ncbi.nlm.nih.gov/pubmed/31871187 http://dx.doi.org/10.1073/pnas.1908691117

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