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Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses
OBJECTIVE: Systematic reviews and meta-analyses have revealed the associations between H. pylori infection and various health outcomes. We aimed to evaluate the strength and breadth of evidence on the associations. DESIGN: Umbrella review of systematic reviews and meta-analyses. SETTING: No settings...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955574/ https://www.ncbi.nlm.nih.gov/pubmed/31924635 http://dx.doi.org/10.1136/bmjopen-2019-031951 |
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author | Li, Liqun Tan, Jinjing Liu, Lijian Li, Jianfeng Chen, Guangwen Chen, Mingbing Xie, Jieru Song, Qingzeng Huang, Xiaoyan Xie, Sheng |
author_facet | Li, Liqun Tan, Jinjing Liu, Lijian Li, Jianfeng Chen, Guangwen Chen, Mingbing Xie, Jieru Song, Qingzeng Huang, Xiaoyan Xie, Sheng |
author_sort | Li, Liqun |
collection | PubMed |
description | OBJECTIVE: Systematic reviews and meta-analyses have revealed the associations between H. pylori infection and various health outcomes. We aimed to evaluate the strength and breadth of evidence on the associations. DESIGN: Umbrella review of systematic reviews and meta-analyses. SETTING: No settings. PARTICIPANTS: No patients involved. DATA SOURCES: Embase, PubMed, Web of Science, Cochrane Library Databases, CNKI, VIP database and Wangfang database from inception to February 1, 2019. OUTCOMES MEASURES: Diverse diseases (such as cancer and ischaemic heart disease). RESULTS: Sixty articles reporting 88 unique outcomes met the eligible criteria. 74 unique outcomes had nominal significance (p<0.05). Of the outcomes with significance, 61 had harmful associations and 13 had beneficial associations. Furthermore, 73% (64) of the outcomes exhibited significant heterogeneity . Of the these meta-analyses, 32 had moderate to high heterogeneity (I(2)=50%–75%) and 24 had high heterogeneity (I(2)>75%). Moreover, 20% exhibited publication bias (p<0.1). In addition, 97% of the methodological qualities were rated ‘critically low’. 36% of the evidence qualities of outcomes were rated ‘low’, 56% of the evidence qualities were rated ‘very low’ and 8% of the evidence qualities were rated ‘moderate’. H. pylori infection may be associated with an increased risk of five diseases and a decreased risk of irritable bowel syndrome. CONCLUSION: Although 60 meta-analyses explored 88 unique outcomes, moderate quality evidence only existed for six outcomes with statistical significance. H. pylori infection may be associated with a decreased risk of irritable bowel syndrome and an increased risk of hypertriglyceridemia, chronic cholecystitis and cholelithiasis, gestational diabetes mellitus, gastric cancer and systemic sclerosis. TRIAL REGISTRATION: CRD42019124680. |
format | Online Article Text |
id | pubmed-6955574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-69555742020-01-27 Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses Li, Liqun Tan, Jinjing Liu, Lijian Li, Jianfeng Chen, Guangwen Chen, Mingbing Xie, Jieru Song, Qingzeng Huang, Xiaoyan Xie, Sheng BMJ Open Infectious Diseases OBJECTIVE: Systematic reviews and meta-analyses have revealed the associations between H. pylori infection and various health outcomes. We aimed to evaluate the strength and breadth of evidence on the associations. DESIGN: Umbrella review of systematic reviews and meta-analyses. SETTING: No settings. PARTICIPANTS: No patients involved. DATA SOURCES: Embase, PubMed, Web of Science, Cochrane Library Databases, CNKI, VIP database and Wangfang database from inception to February 1, 2019. OUTCOMES MEASURES: Diverse diseases (such as cancer and ischaemic heart disease). RESULTS: Sixty articles reporting 88 unique outcomes met the eligible criteria. 74 unique outcomes had nominal significance (p<0.05). Of the outcomes with significance, 61 had harmful associations and 13 had beneficial associations. Furthermore, 73% (64) of the outcomes exhibited significant heterogeneity . Of the these meta-analyses, 32 had moderate to high heterogeneity (I(2)=50%–75%) and 24 had high heterogeneity (I(2)>75%). Moreover, 20% exhibited publication bias (p<0.1). In addition, 97% of the methodological qualities were rated ‘critically low’. 36% of the evidence qualities of outcomes were rated ‘low’, 56% of the evidence qualities were rated ‘very low’ and 8% of the evidence qualities were rated ‘moderate’. H. pylori infection may be associated with an increased risk of five diseases and a decreased risk of irritable bowel syndrome. CONCLUSION: Although 60 meta-analyses explored 88 unique outcomes, moderate quality evidence only existed for six outcomes with statistical significance. H. pylori infection may be associated with a decreased risk of irritable bowel syndrome and an increased risk of hypertriglyceridemia, chronic cholecystitis and cholelithiasis, gestational diabetes mellitus, gastric cancer and systemic sclerosis. TRIAL REGISTRATION: CRD42019124680. BMJ Publishing Group 2020-01-09 /pmc/articles/PMC6955574/ /pubmed/31924635 http://dx.doi.org/10.1136/bmjopen-2019-031951 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Infectious Diseases Li, Liqun Tan, Jinjing Liu, Lijian Li, Jianfeng Chen, Guangwen Chen, Mingbing Xie, Jieru Song, Qingzeng Huang, Xiaoyan Xie, Sheng Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses |
title | Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses |
title_full | Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses |
title_fullStr | Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses |
title_full_unstemmed | Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses |
title_short | Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses |
title_sort | association between h. pylori infection and health outcomes: an umbrella review of systematic reviews and meta-analyses |
topic | Infectious Diseases |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955574/ https://www.ncbi.nlm.nih.gov/pubmed/31924635 http://dx.doi.org/10.1136/bmjopen-2019-031951 |
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