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Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses

OBJECTIVE: Systematic reviews and meta-analyses have revealed the associations between H. pylori infection and various health outcomes. We aimed to evaluate the strength and breadth of evidence on the associations. DESIGN: Umbrella review of systematic reviews and meta-analyses. SETTING: No settings...

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Autores principales: Li, Liqun, Tan, Jinjing, Liu, Lijian, Li, Jianfeng, Chen, Guangwen, Chen, Mingbing, Xie, Jieru, Song, Qingzeng, Huang, Xiaoyan, Xie, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955574/
https://www.ncbi.nlm.nih.gov/pubmed/31924635
http://dx.doi.org/10.1136/bmjopen-2019-031951
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author Li, Liqun
Tan, Jinjing
Liu, Lijian
Li, Jianfeng
Chen, Guangwen
Chen, Mingbing
Xie, Jieru
Song, Qingzeng
Huang, Xiaoyan
Xie, Sheng
author_facet Li, Liqun
Tan, Jinjing
Liu, Lijian
Li, Jianfeng
Chen, Guangwen
Chen, Mingbing
Xie, Jieru
Song, Qingzeng
Huang, Xiaoyan
Xie, Sheng
author_sort Li, Liqun
collection PubMed
description OBJECTIVE: Systematic reviews and meta-analyses have revealed the associations between H. pylori infection and various health outcomes. We aimed to evaluate the strength and breadth of evidence on the associations. DESIGN: Umbrella review of systematic reviews and meta-analyses. SETTING: No settings. PARTICIPANTS: No patients involved. DATA SOURCES: Embase, PubMed, Web of Science, Cochrane Library Databases, CNKI, VIP database and Wangfang database from inception to February 1, 2019. OUTCOMES MEASURES: Diverse diseases (such as cancer and ischaemic heart disease). RESULTS: Sixty articles reporting 88 unique outcomes met the eligible criteria. 74 unique outcomes had nominal significance (p<0.05). Of the outcomes with significance, 61 had harmful associations and 13 had beneficial associations. Furthermore, 73% (64) of the outcomes exhibited significant heterogeneity . Of the these meta-analyses, 32 had moderate to high heterogeneity (I(2)=50%–75%) and 24 had high heterogeneity (I(2)>75%). Moreover, 20% exhibited publication bias (p<0.1). In addition, 97% of the methodological qualities were rated ‘critically low’. 36% of the evidence qualities of outcomes were rated ‘low’, 56% of the evidence qualities were rated ‘very low’ and 8% of the evidence qualities were rated ‘moderate’. H. pylori infection may be associated with an increased risk of five diseases and a decreased risk of irritable bowel syndrome. CONCLUSION: Although 60 meta-analyses explored 88 unique outcomes, moderate quality evidence only existed for six outcomes with statistical significance. H. pylori infection may be associated with a decreased risk of irritable bowel syndrome and an increased risk of hypertriglyceridemia, chronic cholecystitis and cholelithiasis, gestational diabetes mellitus, gastric cancer and systemic sclerosis. TRIAL REGISTRATION: CRD42019124680.
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spelling pubmed-69555742020-01-27 Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses Li, Liqun Tan, Jinjing Liu, Lijian Li, Jianfeng Chen, Guangwen Chen, Mingbing Xie, Jieru Song, Qingzeng Huang, Xiaoyan Xie, Sheng BMJ Open Infectious Diseases OBJECTIVE: Systematic reviews and meta-analyses have revealed the associations between H. pylori infection and various health outcomes. We aimed to evaluate the strength and breadth of evidence on the associations. DESIGN: Umbrella review of systematic reviews and meta-analyses. SETTING: No settings. PARTICIPANTS: No patients involved. DATA SOURCES: Embase, PubMed, Web of Science, Cochrane Library Databases, CNKI, VIP database and Wangfang database from inception to February 1, 2019. OUTCOMES MEASURES: Diverse diseases (such as cancer and ischaemic heart disease). RESULTS: Sixty articles reporting 88 unique outcomes met the eligible criteria. 74 unique outcomes had nominal significance (p<0.05). Of the outcomes with significance, 61 had harmful associations and 13 had beneficial associations. Furthermore, 73% (64) of the outcomes exhibited significant heterogeneity . Of the these meta-analyses, 32 had moderate to high heterogeneity (I(2)=50%–75%) and 24 had high heterogeneity (I(2)>75%). Moreover, 20% exhibited publication bias (p<0.1). In addition, 97% of the methodological qualities were rated ‘critically low’. 36% of the evidence qualities of outcomes were rated ‘low’, 56% of the evidence qualities were rated ‘very low’ and 8% of the evidence qualities were rated ‘moderate’. H. pylori infection may be associated with an increased risk of five diseases and a decreased risk of irritable bowel syndrome. CONCLUSION: Although 60 meta-analyses explored 88 unique outcomes, moderate quality evidence only existed for six outcomes with statistical significance. H. pylori infection may be associated with a decreased risk of irritable bowel syndrome and an increased risk of hypertriglyceridemia, chronic cholecystitis and cholelithiasis, gestational diabetes mellitus, gastric cancer and systemic sclerosis. TRIAL REGISTRATION: CRD42019124680. BMJ Publishing Group 2020-01-09 /pmc/articles/PMC6955574/ /pubmed/31924635 http://dx.doi.org/10.1136/bmjopen-2019-031951 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Infectious Diseases
Li, Liqun
Tan, Jinjing
Liu, Lijian
Li, Jianfeng
Chen, Guangwen
Chen, Mingbing
Xie, Jieru
Song, Qingzeng
Huang, Xiaoyan
Xie, Sheng
Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses
title Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses
title_full Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses
title_fullStr Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses
title_full_unstemmed Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses
title_short Association between H. pylori infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses
title_sort association between h. pylori infection and health outcomes: an umbrella review of systematic reviews and meta-analyses
topic Infectious Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955574/
https://www.ncbi.nlm.nih.gov/pubmed/31924635
http://dx.doi.org/10.1136/bmjopen-2019-031951
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