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Helicobacter pylori, Vascular Risk Factors and Cognition in U.S. Older Adults

Previous studies suggested that Helicobacter pylori infection could be a risk factor for stroke, dementia, and Alzheimer’s disease (AD). The authors examined data from participants, 60 years old and older in the Third National Health and Nutrition Examination Survey (NHANES-III) to assess the relati...

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Autores principales: Cárdenas, Víctor M., Boller, François, Román, Gustavo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955675/
https://www.ncbi.nlm.nih.gov/pubmed/31842501
http://dx.doi.org/10.3390/brainsci9120370
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author Cárdenas, Víctor M.
Boller, François
Román, Gustavo C.
author_facet Cárdenas, Víctor M.
Boller, François
Román, Gustavo C.
author_sort Cárdenas, Víctor M.
collection PubMed
description Previous studies suggested that Helicobacter pylori infection could be a risk factor for stroke, dementia, and Alzheimer’s disease (AD). The authors examined data from participants, 60 years old and older in the Third National Health and Nutrition Examination Survey (NHANES-III) to assess the relation between Helicobacter pylori infection and results of the Mini-Mental State Examination (n = 1860) using logistic regression analysis controlling for age, gender, race/ethnicity, education, poverty and history of medically diagnosed diabetes. Moreover, we examined performance on the digit-symbol substitution test (DSST) of 1031 participants in the 1999–2000 NHANES according to their H. pylori infection status controlling for potential confounders using multiple linear regression analyses. In 1988–1991, older adults infected with CagA strains of H. pylori had a 50% borderline statistically significant increased level of cognitive impairment, as measured by low Mini-Mental State Examination (MMSE) scores (age–education adjusted prevalence ratio: 1.5; 95% confidence interval: 1.0, 2.0). In 1999–2000, older US adults infected with H. pylori scored 2.6 fewer points in the DSST than those uninfected (mean adjusted difference: −2.6; 95% confidence interval −5.1, −0.1). The authors concluded that H. pylori infection might be a risk factor for cognitive decline in the elderly. They also found that low cobalamin and elevated homocysteine were associated with cognitive impairment.
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spelling pubmed-69556752020-01-23 Helicobacter pylori, Vascular Risk Factors and Cognition in U.S. Older Adults Cárdenas, Víctor M. Boller, François Román, Gustavo C. Brain Sci Article Previous studies suggested that Helicobacter pylori infection could be a risk factor for stroke, dementia, and Alzheimer’s disease (AD). The authors examined data from participants, 60 years old and older in the Third National Health and Nutrition Examination Survey (NHANES-III) to assess the relation between Helicobacter pylori infection and results of the Mini-Mental State Examination (n = 1860) using logistic regression analysis controlling for age, gender, race/ethnicity, education, poverty and history of medically diagnosed diabetes. Moreover, we examined performance on the digit-symbol substitution test (DSST) of 1031 participants in the 1999–2000 NHANES according to their H. pylori infection status controlling for potential confounders using multiple linear regression analyses. In 1988–1991, older adults infected with CagA strains of H. pylori had a 50% borderline statistically significant increased level of cognitive impairment, as measured by low Mini-Mental State Examination (MMSE) scores (age–education adjusted prevalence ratio: 1.5; 95% confidence interval: 1.0, 2.0). In 1999–2000, older US adults infected with H. pylori scored 2.6 fewer points in the DSST than those uninfected (mean adjusted difference: −2.6; 95% confidence interval −5.1, −0.1). The authors concluded that H. pylori infection might be a risk factor for cognitive decline in the elderly. They also found that low cobalamin and elevated homocysteine were associated with cognitive impairment. MDPI 2019-12-12 /pmc/articles/PMC6955675/ /pubmed/31842501 http://dx.doi.org/10.3390/brainsci9120370 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cárdenas, Víctor M.
Boller, François
Román, Gustavo C.
Helicobacter pylori, Vascular Risk Factors and Cognition in U.S. Older Adults
title Helicobacter pylori, Vascular Risk Factors and Cognition in U.S. Older Adults
title_full Helicobacter pylori, Vascular Risk Factors and Cognition in U.S. Older Adults
title_fullStr Helicobacter pylori, Vascular Risk Factors and Cognition in U.S. Older Adults
title_full_unstemmed Helicobacter pylori, Vascular Risk Factors and Cognition in U.S. Older Adults
title_short Helicobacter pylori, Vascular Risk Factors and Cognition in U.S. Older Adults
title_sort helicobacter pylori, vascular risk factors and cognition in u.s. older adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955675/
https://www.ncbi.nlm.nih.gov/pubmed/31842501
http://dx.doi.org/10.3390/brainsci9120370
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