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Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation

Thermal conductivity is a material specific property, which influences many aspects of pharmaceutical development, such as processing, modelling, analysis, and the development of novel formulation approaches. We have presented a method to measure thermal conductivity of small molecule organic glasse...

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Detalles Bibliográficos
Autores principales: Karl, Maximilian, Rantanen, Jukka, Rades, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955963/
https://www.ncbi.nlm.nih.gov/pubmed/31835607
http://dx.doi.org/10.3390/pharmaceutics11120670
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author Karl, Maximilian
Rantanen, Jukka
Rades, Thomas
author_facet Karl, Maximilian
Rantanen, Jukka
Rades, Thomas
author_sort Karl, Maximilian
collection PubMed
description Thermal conductivity is a material specific property, which influences many aspects of pharmaceutical development, such as processing, modelling, analysis, and the development of novel formulation approaches. We have presented a method to measure thermal conductivity of small molecule organic glasses, based on a vacuum molding sample preparation technique combined with modulated differential scanning calorimetry. The method is applied to the two amorphous model compounds indomethacin and celecoxib. The measured values of below 0.2 W/m °C indicate very low thermal conductivity of the amorphous compounds, within the range of organic liquids and low conducting polymers.
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spelling pubmed-69559632020-01-23 Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation Karl, Maximilian Rantanen, Jukka Rades, Thomas Pharmaceutics Communication Thermal conductivity is a material specific property, which influences many aspects of pharmaceutical development, such as processing, modelling, analysis, and the development of novel formulation approaches. We have presented a method to measure thermal conductivity of small molecule organic glasses, based on a vacuum molding sample preparation technique combined with modulated differential scanning calorimetry. The method is applied to the two amorphous model compounds indomethacin and celecoxib. The measured values of below 0.2 W/m °C indicate very low thermal conductivity of the amorphous compounds, within the range of organic liquids and low conducting polymers. MDPI 2019-12-10 /pmc/articles/PMC6955963/ /pubmed/31835607 http://dx.doi.org/10.3390/pharmaceutics11120670 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Karl, Maximilian
Rantanen, Jukka
Rades, Thomas
Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation
title Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation
title_full Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation
title_fullStr Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation
title_full_unstemmed Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation
title_short Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation
title_sort determining thermal conductivity of small molecule amorphous drugs with modulated differential scanning calorimetry and vacuum molding sample preparation
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955963/
https://www.ncbi.nlm.nih.gov/pubmed/31835607
http://dx.doi.org/10.3390/pharmaceutics11120670
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