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Bacteriophage and the Innate Immune System: Access and Signaling
Bacteriophage and the bacteria they infect are the dominant members of the gastrointestinal microbiome. While bacteria are known to be central to maintenance of the structure, function, and health of the microbiome, it has only recently been recognized that phage too might serve a critical function....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956183/ https://www.ncbi.nlm.nih.gov/pubmed/31795262 http://dx.doi.org/10.3390/microorganisms7120625 |
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author | Carroll-Portillo, Amanda Lin, Henry C. |
author_facet | Carroll-Portillo, Amanda Lin, Henry C. |
author_sort | Carroll-Portillo, Amanda |
collection | PubMed |
description | Bacteriophage and the bacteria they infect are the dominant members of the gastrointestinal microbiome. While bacteria are known to be central to maintenance of the structure, function, and health of the microbiome, it has only recently been recognized that phage too might serve a critical function. Along these lines, bacteria are not the only cells that are influenced by bacteriophage, and there is growing evidence of bacteriophage effects on epithelial, endothelial, and immune cells. The innate immune system is essential to protecting the Eukaryotic host from invading microorganisms, and bacteriophage have been demonstrated to interact with innate immune cells regularly. Here, we conduct a systematic review of the varying mechanisms allowing bacteriophage to access and interact with cells of the innate immune system and propose the potential importance of these interactions. |
format | Online Article Text |
id | pubmed-6956183 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69561832020-01-23 Bacteriophage and the Innate Immune System: Access and Signaling Carroll-Portillo, Amanda Lin, Henry C. Microorganisms Review Bacteriophage and the bacteria they infect are the dominant members of the gastrointestinal microbiome. While bacteria are known to be central to maintenance of the structure, function, and health of the microbiome, it has only recently been recognized that phage too might serve a critical function. Along these lines, bacteria are not the only cells that are influenced by bacteriophage, and there is growing evidence of bacteriophage effects on epithelial, endothelial, and immune cells. The innate immune system is essential to protecting the Eukaryotic host from invading microorganisms, and bacteriophage have been demonstrated to interact with innate immune cells regularly. Here, we conduct a systematic review of the varying mechanisms allowing bacteriophage to access and interact with cells of the innate immune system and propose the potential importance of these interactions. MDPI 2019-11-28 /pmc/articles/PMC6956183/ /pubmed/31795262 http://dx.doi.org/10.3390/microorganisms7120625 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Carroll-Portillo, Amanda Lin, Henry C. Bacteriophage and the Innate Immune System: Access and Signaling |
title | Bacteriophage and the Innate Immune System: Access and Signaling |
title_full | Bacteriophage and the Innate Immune System: Access and Signaling |
title_fullStr | Bacteriophage and the Innate Immune System: Access and Signaling |
title_full_unstemmed | Bacteriophage and the Innate Immune System: Access and Signaling |
title_short | Bacteriophage and the Innate Immune System: Access and Signaling |
title_sort | bacteriophage and the innate immune system: access and signaling |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956183/ https://www.ncbi.nlm.nih.gov/pubmed/31795262 http://dx.doi.org/10.3390/microorganisms7120625 |
work_keys_str_mv | AT carrollportilloamanda bacteriophageandtheinnateimmunesystemaccessandsignaling AT linhenryc bacteriophageandtheinnateimmunesystemaccessandsignaling |