Cargando…

Evaluation of heavy metals and metabolites in the urine of patients with breast cancer

Epidemiologic studies demonstrated that the environment serves a crucial role in cancer development. Heavy metals, including arsenic (As), cadmium (cd), chromium (Cr), lead and mercury, are considered to be carcinogens or co-carcinogens. Furthermore, Cd has been detected in breast cancer (BC) tissue...

Descripción completa

Detalles Bibliográficos
Autores principales: Men, Yuhao, Li, Ling, Zhang, Fen, Kong, Xueyuan, Zhang, Weidong, Hao, Chongli, Wang, Guotian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956222/
https://www.ncbi.nlm.nih.gov/pubmed/31966065
http://dx.doi.org/10.3892/ol.2019.11206
_version_ 1783487110921060352
author Men, Yuhao
Li, Ling
Zhang, Fen
Kong, Xueyuan
Zhang, Weidong
Hao, Chongli
Wang, Guotian
author_facet Men, Yuhao
Li, Ling
Zhang, Fen
Kong, Xueyuan
Zhang, Weidong
Hao, Chongli
Wang, Guotian
author_sort Men, Yuhao
collection PubMed
description Epidemiologic studies demonstrated that the environment serves a crucial role in cancer development. Heavy metals, including arsenic (As), cadmium (cd), chromium (Cr), lead and mercury, are considered to be carcinogens or co-carcinogens. Furthermore, Cd has been detected in breast cancer (BC) tissue at high concentrations. The present study aimed to investigate the correlation between heavy metals detected in urine and urine metabolome of patients with BC, and their association with cancer development. Nuclear magnetic resonance was used to determine urine metabolites and an inductively coupled plasma mass spectrometry system was used to detect heavy metals in urine samples. The results demonstrated that Cd was markedly increased in the urine of patients with BC compared with the control population (approximately 2-fold). Cr and As were also increased in the urine of patients with BC. In addition, numerous small molecule metabolites were altered in the urine of patients with BC compared with the control population. This study also demonstrated that alterations in small molecule metabolites in the urine of patients with BC were very similar to results from a previous report. These findings indicated that environmental exposure to Cd, As, or Cr could influence the urine levels of metabolites, which may be involved in BC development. Further investigation is therefore required to examine a larger range of samples from different countries or areas in order to understand the impact of heavy metals on metabolism and BC development.
format Online
Article
Text
id pubmed-6956222
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-69562222020-01-21 Evaluation of heavy metals and metabolites in the urine of patients with breast cancer Men, Yuhao Li, Ling Zhang, Fen Kong, Xueyuan Zhang, Weidong Hao, Chongli Wang, Guotian Oncol Lett Articles Epidemiologic studies demonstrated that the environment serves a crucial role in cancer development. Heavy metals, including arsenic (As), cadmium (cd), chromium (Cr), lead and mercury, are considered to be carcinogens or co-carcinogens. Furthermore, Cd has been detected in breast cancer (BC) tissue at high concentrations. The present study aimed to investigate the correlation between heavy metals detected in urine and urine metabolome of patients with BC, and their association with cancer development. Nuclear magnetic resonance was used to determine urine metabolites and an inductively coupled plasma mass spectrometry system was used to detect heavy metals in urine samples. The results demonstrated that Cd was markedly increased in the urine of patients with BC compared with the control population (approximately 2-fold). Cr and As were also increased in the urine of patients with BC. In addition, numerous small molecule metabolites were altered in the urine of patients with BC compared with the control population. This study also demonstrated that alterations in small molecule metabolites in the urine of patients with BC were very similar to results from a previous report. These findings indicated that environmental exposure to Cd, As, or Cr could influence the urine levels of metabolites, which may be involved in BC development. Further investigation is therefore required to examine a larger range of samples from different countries or areas in order to understand the impact of heavy metals on metabolism and BC development. D.A. Spandidos 2020-02 2019-12-11 /pmc/articles/PMC6956222/ /pubmed/31966065 http://dx.doi.org/10.3892/ol.2019.11206 Text en Copyright: © Men et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Men, Yuhao
Li, Ling
Zhang, Fen
Kong, Xueyuan
Zhang, Weidong
Hao, Chongli
Wang, Guotian
Evaluation of heavy metals and metabolites in the urine of patients with breast cancer
title Evaluation of heavy metals and metabolites in the urine of patients with breast cancer
title_full Evaluation of heavy metals and metabolites in the urine of patients with breast cancer
title_fullStr Evaluation of heavy metals and metabolites in the urine of patients with breast cancer
title_full_unstemmed Evaluation of heavy metals and metabolites in the urine of patients with breast cancer
title_short Evaluation of heavy metals and metabolites in the urine of patients with breast cancer
title_sort evaluation of heavy metals and metabolites in the urine of patients with breast cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956222/
https://www.ncbi.nlm.nih.gov/pubmed/31966065
http://dx.doi.org/10.3892/ol.2019.11206
work_keys_str_mv AT menyuhao evaluationofheavymetalsandmetabolitesintheurineofpatientswithbreastcancer
AT liling evaluationofheavymetalsandmetabolitesintheurineofpatientswithbreastcancer
AT zhangfen evaluationofheavymetalsandmetabolitesintheurineofpatientswithbreastcancer
AT kongxueyuan evaluationofheavymetalsandmetabolitesintheurineofpatientswithbreastcancer
AT zhangweidong evaluationofheavymetalsandmetabolitesintheurineofpatientswithbreastcancer
AT haochongli evaluationofheavymetalsandmetabolitesintheurineofpatientswithbreastcancer
AT wangguotian evaluationofheavymetalsandmetabolitesintheurineofpatientswithbreastcancer