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Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery
In order to evaluate the potential of a technology platform based on hyaluronan copolymers grafted with propargylated ferulate fluorophores (HA-FA-Pg) in the development of drug delivery systems, the propargyl groups of HA-FA-Pg derivatives were employed with oleic acid (OA) or stearic acid (SA) res...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956235/ https://www.ncbi.nlm.nih.gov/pubmed/31842344 http://dx.doi.org/10.3390/pharmaceutics11120675 |
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author | Paolino, Marco Licciardi, Mariano Savoca, Cristina Giammona, Gaetano Modica De Mohac, Laura Reale, Annalisa Giuliani, Germano Komber, Hartmut Donati, Alessandro Leone, Gemma Magnani, Agnese Anzini, Maurizio Cappelli, Andrea |
author_facet | Paolino, Marco Licciardi, Mariano Savoca, Cristina Giammona, Gaetano Modica De Mohac, Laura Reale, Annalisa Giuliani, Germano Komber, Hartmut Donati, Alessandro Leone, Gemma Magnani, Agnese Anzini, Maurizio Cappelli, Andrea |
author_sort | Paolino, Marco |
collection | PubMed |
description | In order to evaluate the potential of a technology platform based on hyaluronan copolymers grafted with propargylated ferulate fluorophores (HA-FA-Pg) in the development of drug delivery systems, the propargyl groups of HA-FA-Pg derivatives were employed with oleic acid (OA) or stearic acid (SA) residues across a biocompatible hexa(ethylene glycol) (HEG) spacer. The designed materials (i.e., HA-FA-HEG-OA or HA-FA-HEG-SA) showed clear-cut aggregation features in an aqueous environment, as confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM), generating nanoaggregate systems. In fact, HA-FA-HEG-OA and HA-FA-HEG-SA derivatives showed the property to create self-assembled cytocompatible nanostructured aggregates in water, thanks to the simultaneous presence of hydrophilic portions in the polymeric backbone, such as hyaluronic acid, and hydrophobic portions in the side chains. Furthermore, the designed materials interact with living cells showing a high degree of cytocompatibility. The potential ability of nanosystems to load pharmacologically active molecules was assessed by the physical entrapment of olanzapine into both polymeric systems. The drug loading evaluation demonstrated that the nanoparticles are able to incorporate a good quantity of olanzapine, as well as improve drug solubility, release profile, and cytocompatibility. |
format | Online Article Text |
id | pubmed-6956235 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69562352020-01-23 Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery Paolino, Marco Licciardi, Mariano Savoca, Cristina Giammona, Gaetano Modica De Mohac, Laura Reale, Annalisa Giuliani, Germano Komber, Hartmut Donati, Alessandro Leone, Gemma Magnani, Agnese Anzini, Maurizio Cappelli, Andrea Pharmaceutics Article In order to evaluate the potential of a technology platform based on hyaluronan copolymers grafted with propargylated ferulate fluorophores (HA-FA-Pg) in the development of drug delivery systems, the propargyl groups of HA-FA-Pg derivatives were employed with oleic acid (OA) or stearic acid (SA) residues across a biocompatible hexa(ethylene glycol) (HEG) spacer. The designed materials (i.e., HA-FA-HEG-OA or HA-FA-HEG-SA) showed clear-cut aggregation features in an aqueous environment, as confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM), generating nanoaggregate systems. In fact, HA-FA-HEG-OA and HA-FA-HEG-SA derivatives showed the property to create self-assembled cytocompatible nanostructured aggregates in water, thanks to the simultaneous presence of hydrophilic portions in the polymeric backbone, such as hyaluronic acid, and hydrophobic portions in the side chains. Furthermore, the designed materials interact with living cells showing a high degree of cytocompatibility. The potential ability of nanosystems to load pharmacologically active molecules was assessed by the physical entrapment of olanzapine into both polymeric systems. The drug loading evaluation demonstrated that the nanoparticles are able to incorporate a good quantity of olanzapine, as well as improve drug solubility, release profile, and cytocompatibility. MDPI 2019-12-12 /pmc/articles/PMC6956235/ /pubmed/31842344 http://dx.doi.org/10.3390/pharmaceutics11120675 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Paolino, Marco Licciardi, Mariano Savoca, Cristina Giammona, Gaetano Modica De Mohac, Laura Reale, Annalisa Giuliani, Germano Komber, Hartmut Donati, Alessandro Leone, Gemma Magnani, Agnese Anzini, Maurizio Cappelli, Andrea Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery |
title | Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery |
title_full | Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery |
title_fullStr | Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery |
title_full_unstemmed | Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery |
title_short | Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery |
title_sort | hyaluronan graft copolymers bearing fatty-acid residues as self-assembling nanoparticles for olanzapine delivery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956235/ https://www.ncbi.nlm.nih.gov/pubmed/31842344 http://dx.doi.org/10.3390/pharmaceutics11120675 |
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