Cargando…

Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery

In order to evaluate the potential of a technology platform based on hyaluronan copolymers grafted with propargylated ferulate fluorophores (HA-FA-Pg) in the development of drug delivery systems, the propargyl groups of HA-FA-Pg derivatives were employed with oleic acid (OA) or stearic acid (SA) res...

Descripción completa

Detalles Bibliográficos
Autores principales: Paolino, Marco, Licciardi, Mariano, Savoca, Cristina, Giammona, Gaetano, Modica De Mohac, Laura, Reale, Annalisa, Giuliani, Germano, Komber, Hartmut, Donati, Alessandro, Leone, Gemma, Magnani, Agnese, Anzini, Maurizio, Cappelli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956235/
https://www.ncbi.nlm.nih.gov/pubmed/31842344
http://dx.doi.org/10.3390/pharmaceutics11120675
_version_ 1783487113983950848
author Paolino, Marco
Licciardi, Mariano
Savoca, Cristina
Giammona, Gaetano
Modica De Mohac, Laura
Reale, Annalisa
Giuliani, Germano
Komber, Hartmut
Donati, Alessandro
Leone, Gemma
Magnani, Agnese
Anzini, Maurizio
Cappelli, Andrea
author_facet Paolino, Marco
Licciardi, Mariano
Savoca, Cristina
Giammona, Gaetano
Modica De Mohac, Laura
Reale, Annalisa
Giuliani, Germano
Komber, Hartmut
Donati, Alessandro
Leone, Gemma
Magnani, Agnese
Anzini, Maurizio
Cappelli, Andrea
author_sort Paolino, Marco
collection PubMed
description In order to evaluate the potential of a technology platform based on hyaluronan copolymers grafted with propargylated ferulate fluorophores (HA-FA-Pg) in the development of drug delivery systems, the propargyl groups of HA-FA-Pg derivatives were employed with oleic acid (OA) or stearic acid (SA) residues across a biocompatible hexa(ethylene glycol) (HEG) spacer. The designed materials (i.e., HA-FA-HEG-OA or HA-FA-HEG-SA) showed clear-cut aggregation features in an aqueous environment, as confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM), generating nanoaggregate systems. In fact, HA-FA-HEG-OA and HA-FA-HEG-SA derivatives showed the property to create self-assembled cytocompatible nanostructured aggregates in water, thanks to the simultaneous presence of hydrophilic portions in the polymeric backbone, such as hyaluronic acid, and hydrophobic portions in the side chains. Furthermore, the designed materials interact with living cells showing a high degree of cytocompatibility. The potential ability of nanosystems to load pharmacologically active molecules was assessed by the physical entrapment of olanzapine into both polymeric systems. The drug loading evaluation demonstrated that the nanoparticles are able to incorporate a good quantity of olanzapine, as well as improve drug solubility, release profile, and cytocompatibility.
format Online
Article
Text
id pubmed-6956235
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69562352020-01-23 Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery Paolino, Marco Licciardi, Mariano Savoca, Cristina Giammona, Gaetano Modica De Mohac, Laura Reale, Annalisa Giuliani, Germano Komber, Hartmut Donati, Alessandro Leone, Gemma Magnani, Agnese Anzini, Maurizio Cappelli, Andrea Pharmaceutics Article In order to evaluate the potential of a technology platform based on hyaluronan copolymers grafted with propargylated ferulate fluorophores (HA-FA-Pg) in the development of drug delivery systems, the propargyl groups of HA-FA-Pg derivatives were employed with oleic acid (OA) or stearic acid (SA) residues across a biocompatible hexa(ethylene glycol) (HEG) spacer. The designed materials (i.e., HA-FA-HEG-OA or HA-FA-HEG-SA) showed clear-cut aggregation features in an aqueous environment, as confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM), generating nanoaggregate systems. In fact, HA-FA-HEG-OA and HA-FA-HEG-SA derivatives showed the property to create self-assembled cytocompatible nanostructured aggregates in water, thanks to the simultaneous presence of hydrophilic portions in the polymeric backbone, such as hyaluronic acid, and hydrophobic portions in the side chains. Furthermore, the designed materials interact with living cells showing a high degree of cytocompatibility. The potential ability of nanosystems to load pharmacologically active molecules was assessed by the physical entrapment of olanzapine into both polymeric systems. The drug loading evaluation demonstrated that the nanoparticles are able to incorporate a good quantity of olanzapine, as well as improve drug solubility, release profile, and cytocompatibility. MDPI 2019-12-12 /pmc/articles/PMC6956235/ /pubmed/31842344 http://dx.doi.org/10.3390/pharmaceutics11120675 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Paolino, Marco
Licciardi, Mariano
Savoca, Cristina
Giammona, Gaetano
Modica De Mohac, Laura
Reale, Annalisa
Giuliani, Germano
Komber, Hartmut
Donati, Alessandro
Leone, Gemma
Magnani, Agnese
Anzini, Maurizio
Cappelli, Andrea
Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery
title Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery
title_full Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery
title_fullStr Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery
title_full_unstemmed Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery
title_short Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery
title_sort hyaluronan graft copolymers bearing fatty-acid residues as self-assembling nanoparticles for olanzapine delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956235/
https://www.ncbi.nlm.nih.gov/pubmed/31842344
http://dx.doi.org/10.3390/pharmaceutics11120675
work_keys_str_mv AT paolinomarco hyaluronangraftcopolymersbearingfattyacidresiduesasselfassemblingnanoparticlesforolanzapinedelivery
AT licciardimariano hyaluronangraftcopolymersbearingfattyacidresiduesasselfassemblingnanoparticlesforolanzapinedelivery
AT savocacristina hyaluronangraftcopolymersbearingfattyacidresiduesasselfassemblingnanoparticlesforolanzapinedelivery
AT giammonagaetano hyaluronangraftcopolymersbearingfattyacidresiduesasselfassemblingnanoparticlesforolanzapinedelivery
AT modicademohaclaura hyaluronangraftcopolymersbearingfattyacidresiduesasselfassemblingnanoparticlesforolanzapinedelivery
AT realeannalisa hyaluronangraftcopolymersbearingfattyacidresiduesasselfassemblingnanoparticlesforolanzapinedelivery
AT giulianigermano hyaluronangraftcopolymersbearingfattyacidresiduesasselfassemblingnanoparticlesforolanzapinedelivery
AT komberhartmut hyaluronangraftcopolymersbearingfattyacidresiduesasselfassemblingnanoparticlesforolanzapinedelivery
AT donatialessandro hyaluronangraftcopolymersbearingfattyacidresiduesasselfassemblingnanoparticlesforolanzapinedelivery
AT leonegemma hyaluronangraftcopolymersbearingfattyacidresiduesasselfassemblingnanoparticlesforolanzapinedelivery
AT magnaniagnese hyaluronangraftcopolymersbearingfattyacidresiduesasselfassemblingnanoparticlesforolanzapinedelivery
AT anzinimaurizio hyaluronangraftcopolymersbearingfattyacidresiduesasselfassemblingnanoparticlesforolanzapinedelivery
AT cappelliandrea hyaluronangraftcopolymersbearingfattyacidresiduesasselfassemblingnanoparticlesforolanzapinedelivery