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IDH1-R132H mutation radiosensitizes U87MG glioma cells via epigenetic downregulation of TIGAR

Isocitrate dehydrogenase 1 (IDH1) is the most frequently mutated gene in World Health Organization grade II–III and secondary glioma. The majority of IDH1 mutation cases involve the substitution from arginine to histidine at codon 132 (IDH1-R132H). Although the oncogenic role of IDH1-R132H has been...

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Detalles Bibliográficos
Autores principales:	Yin, Narui, Xie, Ting, Zhang, Haowen, Chen, Jian, Yu, Jiahua, Liu, Fenju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956398/ https://www.ncbi.nlm.nih.gov/pubmed/31966064 http://dx.doi.org/10.3892/ol.2019.11148

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