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Expression levels of ARHI and Beclin1 in thyroid cancer and their relationship with clinical pathology and prognosis

Expression levels of autophagy-related genes ARHI and Beclin1 in thyroid cancer and their relationship with clinical pathology and prognosis were investigated. The expression levels of ARHI and Beclin1 proteins in 80 cases of thyroid cancer and adjacent tissues were detected by western blot analysis...

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Autores principales: Zhu, Houwei, Qu, Yanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956424/
https://www.ncbi.nlm.nih.gov/pubmed/31966053
http://dx.doi.org/10.3892/ol.2019.11223
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author Zhu, Houwei
Qu, Yanqing
author_facet Zhu, Houwei
Qu, Yanqing
author_sort Zhu, Houwei
collection PubMed
description Expression levels of autophagy-related genes ARHI and Beclin1 in thyroid cancer and their relationship with clinical pathology and prognosis were investigated. The expression levels of ARHI and Beclin1 proteins in 80 cases of thyroid cancer and adjacent tissues were detected by western blot analysis. According to the expression levels of ARHI and Beclin1, low- and high-expression groups were determined and the relationship of the expression levels with the pathological parameters and prognosis in thyroid cancer was compared between the two groups. The correlation between the ARHI and Beclin1 protein expression level was analyzed by Pearsons correlation analysis. The levels of ARHI and Beclin1 proteins in thyroid cancer tissues were significantly lower than those in adjacent tissues (P<0.05). There was a significant difference in the expression levels of ARHI and Beclin1 in terms of pathological stage and differentiation degree of cancer tissues (P<0.001); however, there was no significant difference in the expression levels of ARHI and Beclin1 for different types of cancer tissues (P>0 05). There was a positive correlation between the expression levels of Beclin1 and ARHI (r=0.5187, P<0.001). The 3-year survival rates of patients with low-expression level of ARHI and Beclin1 proteins were significantly lower than those of patients with high expression (P<0.05). In conclusion, the expression levels of Beclin1 and ARHI were low in thyroid cancer, and were significantly associated with the pathological stage, differentiation degree and prognosis in thyroid cancer. Beclin1 and ARHI can be used as predictors for the development and prognosis of thyroid cancer.
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spelling pubmed-69564242020-01-21 Expression levels of ARHI and Beclin1 in thyroid cancer and their relationship with clinical pathology and prognosis Zhu, Houwei Qu, Yanqing Oncol Lett Articles Expression levels of autophagy-related genes ARHI and Beclin1 in thyroid cancer and their relationship with clinical pathology and prognosis were investigated. The expression levels of ARHI and Beclin1 proteins in 80 cases of thyroid cancer and adjacent tissues were detected by western blot analysis. According to the expression levels of ARHI and Beclin1, low- and high-expression groups were determined and the relationship of the expression levels with the pathological parameters and prognosis in thyroid cancer was compared between the two groups. The correlation between the ARHI and Beclin1 protein expression level was analyzed by Pearsons correlation analysis. The levels of ARHI and Beclin1 proteins in thyroid cancer tissues were significantly lower than those in adjacent tissues (P<0.05). There was a significant difference in the expression levels of ARHI and Beclin1 in terms of pathological stage and differentiation degree of cancer tissues (P<0.001); however, there was no significant difference in the expression levels of ARHI and Beclin1 for different types of cancer tissues (P>0 05). There was a positive correlation between the expression levels of Beclin1 and ARHI (r=0.5187, P<0.001). The 3-year survival rates of patients with low-expression level of ARHI and Beclin1 proteins were significantly lower than those of patients with high expression (P<0.05). In conclusion, the expression levels of Beclin1 and ARHI were low in thyroid cancer, and were significantly associated with the pathological stage, differentiation degree and prognosis in thyroid cancer. Beclin1 and ARHI can be used as predictors for the development and prognosis of thyroid cancer. D.A. Spandidos 2020-02 2019-12-17 /pmc/articles/PMC6956424/ /pubmed/31966053 http://dx.doi.org/10.3892/ol.2019.11223 Text en Copyright: © Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhu, Houwei
Qu, Yanqing
Expression levels of ARHI and Beclin1 in thyroid cancer and their relationship with clinical pathology and prognosis
title Expression levels of ARHI and Beclin1 in thyroid cancer and their relationship with clinical pathology and prognosis
title_full Expression levels of ARHI and Beclin1 in thyroid cancer and their relationship with clinical pathology and prognosis
title_fullStr Expression levels of ARHI and Beclin1 in thyroid cancer and their relationship with clinical pathology and prognosis
title_full_unstemmed Expression levels of ARHI and Beclin1 in thyroid cancer and their relationship with clinical pathology and prognosis
title_short Expression levels of ARHI and Beclin1 in thyroid cancer and their relationship with clinical pathology and prognosis
title_sort expression levels of arhi and beclin1 in thyroid cancer and their relationship with clinical pathology and prognosis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956424/
https://www.ncbi.nlm.nih.gov/pubmed/31966053
http://dx.doi.org/10.3892/ol.2019.11223
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