AQP1 expression in the proximal tubule of diabetic rat kidney

Polyuria is a hallmark symptom and the first clinical manifestation of diabetes mellitus (DM). The glucose that remains in renal tubules was proposed to produce an osmotic effect resulting in polyuria. Although water is reabsorbed in proximal tubules through an aquaporin-1 (AQP1) dependent mechanism...

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Autores principales: Seyahian, Erika A., Cacciagiu, Leornardo, Damiano, Alicia E., Zotta, Elsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956755/
https://www.ncbi.nlm.nih.gov/pubmed/31956716
http://dx.doi.org/10.1016/j.heliyon.2020.e03192
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author Seyahian, Erika A.
Cacciagiu, Leornardo
Damiano, Alicia E.
Zotta, Elsa
author_facet Seyahian, Erika A.
Cacciagiu, Leornardo
Damiano, Alicia E.
Zotta, Elsa
author_sort Seyahian, Erika A.
collection PubMed
description Polyuria is a hallmark symptom and the first clinical manifestation of diabetes mellitus (DM). The glucose that remains in renal tubules was proposed to produce an osmotic effect resulting in polyuria. Although water is reabsorbed in proximal tubules through an aquaporin-1 (AQP1) dependent mechanism, AQP1 role in the genesis of polyuria is unknown. AQP1 expression was studied in a rat model of Type-1 DM at 15-days and 5-months of evolution. A different AQP1 expression pattern was found in both experimental groups, with no changes in AQP1 localization, suggesting that changes in AQP1 may be involved in the development of polyuria.
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spelling pubmed-69567552020-01-17 AQP1 expression in the proximal tubule of diabetic rat kidney Seyahian, Erika A. Cacciagiu, Leornardo Damiano, Alicia E. Zotta, Elsa Heliyon Article Polyuria is a hallmark symptom and the first clinical manifestation of diabetes mellitus (DM). The glucose that remains in renal tubules was proposed to produce an osmotic effect resulting in polyuria. Although water is reabsorbed in proximal tubules through an aquaporin-1 (AQP1) dependent mechanism, AQP1 role in the genesis of polyuria is unknown. AQP1 expression was studied in a rat model of Type-1 DM at 15-days and 5-months of evolution. A different AQP1 expression pattern was found in both experimental groups, with no changes in AQP1 localization, suggesting that changes in AQP1 may be involved in the development of polyuria. Elsevier 2020-01-09 /pmc/articles/PMC6956755/ /pubmed/31956716 http://dx.doi.org/10.1016/j.heliyon.2020.e03192 Text en © 2020 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Seyahian, Erika A.
Cacciagiu, Leornardo
Damiano, Alicia E.
Zotta, Elsa
AQP1 expression in the proximal tubule of diabetic rat kidney
title AQP1 expression in the proximal tubule of diabetic rat kidney
title_full AQP1 expression in the proximal tubule of diabetic rat kidney
title_fullStr AQP1 expression in the proximal tubule of diabetic rat kidney
title_full_unstemmed AQP1 expression in the proximal tubule of diabetic rat kidney
title_short AQP1 expression in the proximal tubule of diabetic rat kidney
title_sort aqp1 expression in the proximal tubule of diabetic rat kidney
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956755/
https://www.ncbi.nlm.nih.gov/pubmed/31956716
http://dx.doi.org/10.1016/j.heliyon.2020.e03192
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