Deubiquitinase USP28 inhibits ubiquitin ligase KLHL2-mediated uridine-cytidine kinase 1 degradation and confers sensitivity to 5'-azacytidine-resistant human leukemia cells

Resistance to the chemotherapeutic drug 5'-azacytidine (5'-AZA) is a major obstacle in the treatment of patients with acute myeloid leukemia (AML). The uridine-cytidine kinase 1 (UCK1) has an established role in activating 5'-AZA and its protein level is significantly downregulated in...

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Detalles Bibliográficos
Autores principales: Zhang, Heng, Huang, He, Feng, Xing, Song, Huiwen, Zhang, Zhiyong, Shen, Aizong, Qiu, Xingfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956814/
https://www.ncbi.nlm.nih.gov/pubmed/31938050
http://dx.doi.org/10.7150/thno.36503

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