The Impact of Antiepileptic Drugs on Thyroid Function in Children with Epilepsy: New Versus Old

OBJECTIVES: To investigate the effects of traditional antiepileptic drugs (AEDs) versus newer AEDs on the thyroid hormone profile of children with epilepsy. MATERIALS & METHODS: A total of 80 children with epilepsy were included in this study and were divided into two groups. Group 1 included 40...

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Detalles Bibliográficos
Autores principales: ELSHORBAGY, Hatem Hamed, BARSEEM, Naglaa Fathy, SULIMAN, Hany Abdelaziz, TALAAT, Eman, AlSHOKARY, Ashraf Hamed, ABDELGHANI, Waleed Elsayed, ABDULSAMEA, Sameh Elsayed, MAKSOUD, Yehia Hamed Abdel, AZAB, Sanaa Mohammed, ELSADEK, Akram Elshafey, NOUR EL DIN, Dalia Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shahid Beheshti University of Medical Sciences 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956958/
https://www.ncbi.nlm.nih.gov/pubmed/32021626
Descripción
Sumario:OBJECTIVES: To investigate the effects of traditional antiepileptic drugs (AEDs) versus newer AEDs on the thyroid hormone profile of children with epilepsy. MATERIALS & METHODS: A total of 80 children with epilepsy were included in this study and were divided into two groups. Group 1 included 40 children with epilepsy on traditional AEDs, and group 2 included 40 children with epilepsy on newer AEDs. Forty healthy children were also included as the control group (group 3). We analyzed the serum levels of free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH). RESULTS: In epileptic children treated with traditional drugs, there was a significant reduction in the serum level of FT4 and a significant increase in TSH concentration, compared to the control group (P<0.001). Conversely, epileptic children treated with newer AEDs showed no significant changes in the serum concentrations of FT3, FT4, and TSH, compared to the control group. CONCLUSION: Traditional AEDs have more significant effects on thyroid hormone profile, compared to newer AEDs.

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