The Impact of Antiepileptic Drugs on Thyroid Function in Children with Epilepsy: New Versus Old

OBJECTIVES: To investigate the effects of traditional antiepileptic drugs (AEDs) versus newer AEDs on the thyroid hormone profile of children with epilepsy. MATERIALS & METHODS: A total of 80 children with epilepsy were included in this study and were divided into two groups. Group 1 included 40...

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Autores principales: ELSHORBAGY, Hatem Hamed, BARSEEM, Naglaa Fathy, SULIMAN, Hany Abdelaziz, TALAAT, Eman, AlSHOKARY, Ashraf Hamed, ABDELGHANI, Waleed Elsayed, ABDULSAMEA, Sameh Elsayed, MAKSOUD, Yehia Hamed Abdel, AZAB, Sanaa Mohammed, ELSADEK, Akram Elshafey, NOUR EL DIN, Dalia Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shahid Beheshti University of Medical Sciences 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956958/
https://www.ncbi.nlm.nih.gov/pubmed/32021626
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author ELSHORBAGY, Hatem Hamed
BARSEEM, Naglaa Fathy
SULIMAN, Hany Abdelaziz
TALAAT, Eman
AlSHOKARY, Ashraf Hamed
ABDELGHANI, Waleed Elsayed
ABDULSAMEA, Sameh Elsayed
MAKSOUD, Yehia Hamed Abdel
AZAB, Sanaa Mohammed
ELSADEK, Akram Elshafey
NOUR EL DIN, Dalia Mohamed
author_facet ELSHORBAGY, Hatem Hamed
BARSEEM, Naglaa Fathy
SULIMAN, Hany Abdelaziz
TALAAT, Eman
AlSHOKARY, Ashraf Hamed
ABDELGHANI, Waleed Elsayed
ABDULSAMEA, Sameh Elsayed
MAKSOUD, Yehia Hamed Abdel
AZAB, Sanaa Mohammed
ELSADEK, Akram Elshafey
NOUR EL DIN, Dalia Mohamed
author_sort ELSHORBAGY, Hatem Hamed
collection PubMed
description OBJECTIVES: To investigate the effects of traditional antiepileptic drugs (AEDs) versus newer AEDs on the thyroid hormone profile of children with epilepsy. MATERIALS & METHODS: A total of 80 children with epilepsy were included in this study and were divided into two groups. Group 1 included 40 children with epilepsy on traditional AEDs, and group 2 included 40 children with epilepsy on newer AEDs. Forty healthy children were also included as the control group (group 3). We analyzed the serum levels of free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH). RESULTS: In epileptic children treated with traditional drugs, there was a significant reduction in the serum level of FT4 and a significant increase in TSH concentration, compared to the control group (P<0.001). Conversely, epileptic children treated with newer AEDs showed no significant changes in the serum concentrations of FT3, FT4, and TSH, compared to the control group. CONCLUSION: Traditional AEDs have more significant effects on thyroid hormone profile, compared to newer AEDs.
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spelling pubmed-69569582020-04-01 The Impact of Antiepileptic Drugs on Thyroid Function in Children with Epilepsy: New Versus Old ELSHORBAGY, Hatem Hamed BARSEEM, Naglaa Fathy SULIMAN, Hany Abdelaziz TALAAT, Eman AlSHOKARY, Ashraf Hamed ABDELGHANI, Waleed Elsayed ABDULSAMEA, Sameh Elsayed MAKSOUD, Yehia Hamed Abdel AZAB, Sanaa Mohammed ELSADEK, Akram Elshafey NOUR EL DIN, Dalia Mohamed Iran J Child Neurol Original Article OBJECTIVES: To investigate the effects of traditional antiepileptic drugs (AEDs) versus newer AEDs on the thyroid hormone profile of children with epilepsy. MATERIALS & METHODS: A total of 80 children with epilepsy were included in this study and were divided into two groups. Group 1 included 40 children with epilepsy on traditional AEDs, and group 2 included 40 children with epilepsy on newer AEDs. Forty healthy children were also included as the control group (group 3). We analyzed the serum levels of free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH). RESULTS: In epileptic children treated with traditional drugs, there was a significant reduction in the serum level of FT4 and a significant increase in TSH concentration, compared to the control group (P<0.001). Conversely, epileptic children treated with newer AEDs showed no significant changes in the serum concentrations of FT3, FT4, and TSH, compared to the control group. CONCLUSION: Traditional AEDs have more significant effects on thyroid hormone profile, compared to newer AEDs. Shahid Beheshti University of Medical Sciences 2020 /pmc/articles/PMC6956958/ /pubmed/32021626 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
ELSHORBAGY, Hatem Hamed
BARSEEM, Naglaa Fathy
SULIMAN, Hany Abdelaziz
TALAAT, Eman
AlSHOKARY, Ashraf Hamed
ABDELGHANI, Waleed Elsayed
ABDULSAMEA, Sameh Elsayed
MAKSOUD, Yehia Hamed Abdel
AZAB, Sanaa Mohammed
ELSADEK, Akram Elshafey
NOUR EL DIN, Dalia Mohamed
The Impact of Antiepileptic Drugs on Thyroid Function in Children with Epilepsy: New Versus Old
title The Impact of Antiepileptic Drugs on Thyroid Function in Children with Epilepsy: New Versus Old
title_full The Impact of Antiepileptic Drugs on Thyroid Function in Children with Epilepsy: New Versus Old
title_fullStr The Impact of Antiepileptic Drugs on Thyroid Function in Children with Epilepsy: New Versus Old
title_full_unstemmed The Impact of Antiepileptic Drugs on Thyroid Function in Children with Epilepsy: New Versus Old
title_short The Impact of Antiepileptic Drugs on Thyroid Function in Children with Epilepsy: New Versus Old
title_sort impact of antiepileptic drugs on thyroid function in children with epilepsy: new versus old
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956958/
https://www.ncbi.nlm.nih.gov/pubmed/32021626
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