Alcohol and Dementia – What is the Link? A Systematic Review

BACKGROUND: Dementia is a globally increasing health issue and since no cure is currently available, prevention is crucial. The consumption of alcohol is a controversially discussed risk factor for dementia. While many previously published epidemiological studies reported a risk reduction by light t...

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Detalles Bibliográficos
Autores principales: Wiegmann, Caspar, Mick, Inge, Brandl, Eva J, Heinz, Andreas, Gutwinski, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957093/
https://www.ncbi.nlm.nih.gov/pubmed/32021202
http://dx.doi.org/10.2147/NDT.S198772
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author Wiegmann, Caspar
Mick, Inge
Brandl, Eva J
Heinz, Andreas
Gutwinski, Stefan
author_facet Wiegmann, Caspar
Mick, Inge
Brandl, Eva J
Heinz, Andreas
Gutwinski, Stefan
author_sort Wiegmann, Caspar
collection PubMed
description BACKGROUND: Dementia is a globally increasing health issue and since no cure is currently available, prevention is crucial. The consumption of alcohol is a controversially discussed risk factor for dementia. While many previously published epidemiological studies reported a risk reduction by light to moderate alcohol consumption, there is no persuasive model of an underlying biochemical mechanism. The purpose of this article is to review current models on alcohol neurotoxicity and dementia and to analyze and compare studies focusing on the epidemiological link between alcohol consumption and the risk of dementia. METHODS: The electronic database Pubmed was searched for studies published between 1994 and 2019 concerning the topic. RESULTS: Available epidemiological studies are not sufficient to verify a protective effect of alcohol on dementia development.
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spelling pubmed-69570932020-02-04 Alcohol and Dementia – What is the Link? A Systematic Review Wiegmann, Caspar Mick, Inge Brandl, Eva J Heinz, Andreas Gutwinski, Stefan Neuropsychiatr Dis Treat Review BACKGROUND: Dementia is a globally increasing health issue and since no cure is currently available, prevention is crucial. The consumption of alcohol is a controversially discussed risk factor for dementia. While many previously published epidemiological studies reported a risk reduction by light to moderate alcohol consumption, there is no persuasive model of an underlying biochemical mechanism. The purpose of this article is to review current models on alcohol neurotoxicity and dementia and to analyze and compare studies focusing on the epidemiological link between alcohol consumption and the risk of dementia. METHODS: The electronic database Pubmed was searched for studies published between 1994 and 2019 concerning the topic. RESULTS: Available epidemiological studies are not sufficient to verify a protective effect of alcohol on dementia development. Dove 2020-01-09 /pmc/articles/PMC6957093/ /pubmed/32021202 http://dx.doi.org/10.2147/NDT.S198772 Text en © 2020 Wiegmann et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Wiegmann, Caspar
Mick, Inge
Brandl, Eva J
Heinz, Andreas
Gutwinski, Stefan
Alcohol and Dementia – What is the Link? A Systematic Review
title Alcohol and Dementia – What is the Link? A Systematic Review
title_full Alcohol and Dementia – What is the Link? A Systematic Review
title_fullStr Alcohol and Dementia – What is the Link? A Systematic Review
title_full_unstemmed Alcohol and Dementia – What is the Link? A Systematic Review
title_short Alcohol and Dementia – What is the Link? A Systematic Review
title_sort alcohol and dementia – what is the link? a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957093/
https://www.ncbi.nlm.nih.gov/pubmed/32021202
http://dx.doi.org/10.2147/NDT.S198772
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