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Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation

OBJECTIVES: To evaluate the predictive performance of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes. METHODS: From June 2014 through September 2018, 114 female volunteers (mean age 58.1±13.3 years; range 28–88 years) with enlarged axi...

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Autores principales: Gregory, Adriana, Denis, Max, Bayat, Mahdi, Kumar, Viksit, Kim, Bae Hyung, Webb, Jeremy, Nayak, Rohit, Adabi, Saba, Meixner, Duane D., Polley, Eric C., Fazzio, Robert T., Fatemi, Mostafa, Alizad, Azra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957145/
https://www.ncbi.nlm.nih.gov/pubmed/31929558
http://dx.doi.org/10.1371/journal.pone.0226994
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author Gregory, Adriana
Denis, Max
Bayat, Mahdi
Kumar, Viksit
Kim, Bae Hyung
Webb, Jeremy
Nayak, Rohit
Adabi, Saba
Meixner, Duane D.
Polley, Eric C.
Fazzio, Robert T.
Fatemi, Mostafa
Alizad, Azra
author_facet Gregory, Adriana
Denis, Max
Bayat, Mahdi
Kumar, Viksit
Kim, Bae Hyung
Webb, Jeremy
Nayak, Rohit
Adabi, Saba
Meixner, Duane D.
Polley, Eric C.
Fazzio, Robert T.
Fatemi, Mostafa
Alizad, Azra
author_sort Gregory, Adriana
collection PubMed
description OBJECTIVES: To evaluate the predictive performance of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes. METHODS: From June 2014 through September 2018, 114 female volunteers (mean age 58.1±13.3 years; range 28–88 years) with enlarged axillary lymph nodes identified by palpation or clinical imaging were prospectively enrolled in the study. Mean, standard deviation and maximum shear wave elastography parameters from 117 lymph nodes were obtained and compared to fine needle aspiration biopsy results. Mann-Whitney U test and ROC curve analysis were performed. RESULTS: The axillary lymph nodes were classified as reactive or metastatic based on the fine needle aspiration outcomes. A statistically significant difference between reactive and metastatic axillary lymph nodes was observed based on comb-push ultrasound shear elastography (CUSE) results (p<0.0001) from mean and maximum elasticity values. Mean elasticity showed the best separation with a ROC analysis resulting in 90.5% sensitivity, 94.4% specificity, 0.97 area under the curve, 95% positive predictive value, and 89.5% negative predictive value with a 30.2-kPa threshold. CONCLUSIONS: CUSE provided a quantifiable parameter that can be used for the assessment of enlarged axillary lymph nodes to differentiate between reactive and metastatic processes.
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spelling pubmed-69571452020-01-26 Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation Gregory, Adriana Denis, Max Bayat, Mahdi Kumar, Viksit Kim, Bae Hyung Webb, Jeremy Nayak, Rohit Adabi, Saba Meixner, Duane D. Polley, Eric C. Fazzio, Robert T. Fatemi, Mostafa Alizad, Azra PLoS One Research Article OBJECTIVES: To evaluate the predictive performance of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes. METHODS: From June 2014 through September 2018, 114 female volunteers (mean age 58.1±13.3 years; range 28–88 years) with enlarged axillary lymph nodes identified by palpation or clinical imaging were prospectively enrolled in the study. Mean, standard deviation and maximum shear wave elastography parameters from 117 lymph nodes were obtained and compared to fine needle aspiration biopsy results. Mann-Whitney U test and ROC curve analysis were performed. RESULTS: The axillary lymph nodes were classified as reactive or metastatic based on the fine needle aspiration outcomes. A statistically significant difference between reactive and metastatic axillary lymph nodes was observed based on comb-push ultrasound shear elastography (CUSE) results (p<0.0001) from mean and maximum elasticity values. Mean elasticity showed the best separation with a ROC analysis resulting in 90.5% sensitivity, 94.4% specificity, 0.97 area under the curve, 95% positive predictive value, and 89.5% negative predictive value with a 30.2-kPa threshold. CONCLUSIONS: CUSE provided a quantifiable parameter that can be used for the assessment of enlarged axillary lymph nodes to differentiate between reactive and metastatic processes. Public Library of Science 2020-01-13 /pmc/articles/PMC6957145/ /pubmed/31929558 http://dx.doi.org/10.1371/journal.pone.0226994 Text en © 2020 Gregory et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gregory, Adriana
Denis, Max
Bayat, Mahdi
Kumar, Viksit
Kim, Bae Hyung
Webb, Jeremy
Nayak, Rohit
Adabi, Saba
Meixner, Duane D.
Polley, Eric C.
Fazzio, Robert T.
Fatemi, Mostafa
Alizad, Azra
Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation
title Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation
title_full Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation
title_fullStr Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation
title_full_unstemmed Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation
title_short Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation
title_sort predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: a preliminary investigation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957145/
https://www.ncbi.nlm.nih.gov/pubmed/31929558
http://dx.doi.org/10.1371/journal.pone.0226994
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