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Characterization of dermal skin innervation in fibromyalgia syndrome
INTRODUCTION: We characterized dermal innervation in patients with fibromyalgia syndrome (FMS) as potential contribution to small fiber pathology. METHODS: Skin biopsies of the calf were collected (86 FMS patients, 35 healthy controls). Skin was immunoreacted with antibodies against protein gene pro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957156/ https://www.ncbi.nlm.nih.gov/pubmed/31929578 http://dx.doi.org/10.1371/journal.pone.0227674 |
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author | Evdokimov, Dimitar Dinkel, Philine Frank, Johanna Sommer, Claudia Üçeyler, Nurcan |
author_facet | Evdokimov, Dimitar Dinkel, Philine Frank, Johanna Sommer, Claudia Üçeyler, Nurcan |
author_sort | Evdokimov, Dimitar |
collection | PubMed |
description | INTRODUCTION: We characterized dermal innervation in patients with fibromyalgia syndrome (FMS) as potential contribution to small fiber pathology. METHODS: Skin biopsies of the calf were collected (86 FMS patients, 35 healthy controls). Skin was immunoreacted with antibodies against protein gene product 9.5, calcitonine gene-related peptide, substance P, CD31, and neurofilament 200 for small fiber subtypes. We assessed two skin sections per patient; on each skin section, two dermal areas (150 x 700 μm each) were investigated for dermal nerve fiber length (DNFL). RESULTS: In FMS patients we found reduced DNFL of fibers with vessel contact compared to healthy controls (p<0.05). There were no differences for the other nerve fiber subtypes. DISCUSSION: We found less dermal nerve fibers in contact with blood vessels in FMS patients than in controls. The pathophysiological relevance of this finding is unclear, but we suggest the possibility of a relationship with impaired thermal tolerance commonly reported by FMS patients. |
format | Online Article Text |
id | pubmed-6957156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-69571562020-01-26 Characterization of dermal skin innervation in fibromyalgia syndrome Evdokimov, Dimitar Dinkel, Philine Frank, Johanna Sommer, Claudia Üçeyler, Nurcan PLoS One Research Article INTRODUCTION: We characterized dermal innervation in patients with fibromyalgia syndrome (FMS) as potential contribution to small fiber pathology. METHODS: Skin biopsies of the calf were collected (86 FMS patients, 35 healthy controls). Skin was immunoreacted with antibodies against protein gene product 9.5, calcitonine gene-related peptide, substance P, CD31, and neurofilament 200 for small fiber subtypes. We assessed two skin sections per patient; on each skin section, two dermal areas (150 x 700 μm each) were investigated for dermal nerve fiber length (DNFL). RESULTS: In FMS patients we found reduced DNFL of fibers with vessel contact compared to healthy controls (p<0.05). There were no differences for the other nerve fiber subtypes. DISCUSSION: We found less dermal nerve fibers in contact with blood vessels in FMS patients than in controls. The pathophysiological relevance of this finding is unclear, but we suggest the possibility of a relationship with impaired thermal tolerance commonly reported by FMS patients. Public Library of Science 2020-01-13 /pmc/articles/PMC6957156/ /pubmed/31929578 http://dx.doi.org/10.1371/journal.pone.0227674 Text en © 2020 Evdokimov et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Evdokimov, Dimitar Dinkel, Philine Frank, Johanna Sommer, Claudia Üçeyler, Nurcan Characterization of dermal skin innervation in fibromyalgia syndrome |
title | Characterization of dermal skin innervation in fibromyalgia syndrome |
title_full | Characterization of dermal skin innervation in fibromyalgia syndrome |
title_fullStr | Characterization of dermal skin innervation in fibromyalgia syndrome |
title_full_unstemmed | Characterization of dermal skin innervation in fibromyalgia syndrome |
title_short | Characterization of dermal skin innervation in fibromyalgia syndrome |
title_sort | characterization of dermal skin innervation in fibromyalgia syndrome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957156/ https://www.ncbi.nlm.nih.gov/pubmed/31929578 http://dx.doi.org/10.1371/journal.pone.0227674 |
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