Cargando…

Characterization of dermal skin innervation in fibromyalgia syndrome

INTRODUCTION: We characterized dermal innervation in patients with fibromyalgia syndrome (FMS) as potential contribution to small fiber pathology. METHODS: Skin biopsies of the calf were collected (86 FMS patients, 35 healthy controls). Skin was immunoreacted with antibodies against protein gene pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Evdokimov, Dimitar, Dinkel, Philine, Frank, Johanna, Sommer, Claudia, Üçeyler, Nurcan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957156/
https://www.ncbi.nlm.nih.gov/pubmed/31929578
http://dx.doi.org/10.1371/journal.pone.0227674
_version_ 1783487268978163712
author Evdokimov, Dimitar
Dinkel, Philine
Frank, Johanna
Sommer, Claudia
Üçeyler, Nurcan
author_facet Evdokimov, Dimitar
Dinkel, Philine
Frank, Johanna
Sommer, Claudia
Üçeyler, Nurcan
author_sort Evdokimov, Dimitar
collection PubMed
description INTRODUCTION: We characterized dermal innervation in patients with fibromyalgia syndrome (FMS) as potential contribution to small fiber pathology. METHODS: Skin biopsies of the calf were collected (86 FMS patients, 35 healthy controls). Skin was immunoreacted with antibodies against protein gene product 9.5, calcitonine gene-related peptide, substance P, CD31, and neurofilament 200 for small fiber subtypes. We assessed two skin sections per patient; on each skin section, two dermal areas (150 x 700 μm each) were investigated for dermal nerve fiber length (DNFL). RESULTS: In FMS patients we found reduced DNFL of fibers with vessel contact compared to healthy controls (p<0.05). There were no differences for the other nerve fiber subtypes. DISCUSSION: We found less dermal nerve fibers in contact with blood vessels in FMS patients than in controls. The pathophysiological relevance of this finding is unclear, but we suggest the possibility of a relationship with impaired thermal tolerance commonly reported by FMS patients.
format Online
Article
Text
id pubmed-6957156
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-69571562020-01-26 Characterization of dermal skin innervation in fibromyalgia syndrome Evdokimov, Dimitar Dinkel, Philine Frank, Johanna Sommer, Claudia Üçeyler, Nurcan PLoS One Research Article INTRODUCTION: We characterized dermal innervation in patients with fibromyalgia syndrome (FMS) as potential contribution to small fiber pathology. METHODS: Skin biopsies of the calf were collected (86 FMS patients, 35 healthy controls). Skin was immunoreacted with antibodies against protein gene product 9.5, calcitonine gene-related peptide, substance P, CD31, and neurofilament 200 for small fiber subtypes. We assessed two skin sections per patient; on each skin section, two dermal areas (150 x 700 μm each) were investigated for dermal nerve fiber length (DNFL). RESULTS: In FMS patients we found reduced DNFL of fibers with vessel contact compared to healthy controls (p<0.05). There were no differences for the other nerve fiber subtypes. DISCUSSION: We found less dermal nerve fibers in contact with blood vessels in FMS patients than in controls. The pathophysiological relevance of this finding is unclear, but we suggest the possibility of a relationship with impaired thermal tolerance commonly reported by FMS patients. Public Library of Science 2020-01-13 /pmc/articles/PMC6957156/ /pubmed/31929578 http://dx.doi.org/10.1371/journal.pone.0227674 Text en © 2020 Evdokimov et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Evdokimov, Dimitar
Dinkel, Philine
Frank, Johanna
Sommer, Claudia
Üçeyler, Nurcan
Characterization of dermal skin innervation in fibromyalgia syndrome
title Characterization of dermal skin innervation in fibromyalgia syndrome
title_full Characterization of dermal skin innervation in fibromyalgia syndrome
title_fullStr Characterization of dermal skin innervation in fibromyalgia syndrome
title_full_unstemmed Characterization of dermal skin innervation in fibromyalgia syndrome
title_short Characterization of dermal skin innervation in fibromyalgia syndrome
title_sort characterization of dermal skin innervation in fibromyalgia syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957156/
https://www.ncbi.nlm.nih.gov/pubmed/31929578
http://dx.doi.org/10.1371/journal.pone.0227674
work_keys_str_mv AT evdokimovdimitar characterizationofdermalskininnervationinfibromyalgiasyndrome
AT dinkelphiline characterizationofdermalskininnervationinfibromyalgiasyndrome
AT frankjohanna characterizationofdermalskininnervationinfibromyalgiasyndrome
AT sommerclaudia characterizationofdermalskininnervationinfibromyalgiasyndrome
AT uceylernurcan characterizationofdermalskininnervationinfibromyalgiasyndrome