Cell-free DNA donor fraction analysis in pediatric and adult heart transplant patients by multiplexed allele-specific quantitative PCR: Validation of a rapid and highly sensitive clinical test for stratification of rejection probability

Lifelong noninvasive rejection monitoring in heart transplant patients is a critical clinical need historically poorly met in adults and unavailable for children and infants. Cell-free DNA (cfDNA) donor-specific fraction (DF), a direct marker of selective donor organ injury, is a promising analytica...

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Detalles Bibliográficos
Autores principales: North, Paula E., Ziegler, Emily, Mahnke, Donna K., Stamm, Karl D., Thomm, Angela, Daft, Paul, Goetsch, Mary, Liang, Huan ling, Baker, Maria Angeles, Vepraskas, Adam, Rosenau, Chris, Dasgupta, Mahua, Simpson, Pippa, Mitchell, Michael E., Tomita-Mitchell, Aoy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957190/
https://www.ncbi.nlm.nih.gov/pubmed/31929557
http://dx.doi.org/10.1371/journal.pone.0227385

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