Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis

Growth and Differentiation Factor 5 (GDF5) is a key risk locus for osteoarthritis (OA). However, little is known regarding regulation of Gdf5 expression following joint tissue damage. Here, we employed Gdf5-LacZ reporter mouse lines to assess the spatiotemporal activity of Gdf5 regulatory sequences...

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Detalles Bibliográficos
Autores principales: Kania, Karolina, Colella, Fabio, Riemen, Anna H. K., Wang, Hui, Howard, Kenneth A., Aigner, Thomas, Dell’Accio, Francesco, Capellini, Terence D., Roelofs, Anke J., De Bari, Cosimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957535/
https://www.ncbi.nlm.nih.gov/pubmed/31932746
http://dx.doi.org/10.1038/s41598-019-57011-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957535/
https://www.ncbi.nlm.nih.gov/pubmed/31932746
http://dx.doi.org/10.1038/s41598-019-57011-8

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