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Simultaneous emission and attenuation reconstruction in time-of-flight PET using a reference object

BACKGROUND: Simultaneous reconstruction of emission and attenuation images in time-of-flight (TOF) positron emission tomography (PET) does not provide a unique solution. In this study, we propose to solve this limitation by including additional information given by a reference object with known atte...

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Autores principales: García-Pérez, Pablo, España, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957598/
https://www.ncbi.nlm.nih.gov/pubmed/31932984
http://dx.doi.org/10.1186/s40658-020-0272-9
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author García-Pérez, Pablo
España, Samuel
author_facet García-Pérez, Pablo
España, Samuel
author_sort García-Pérez, Pablo
collection PubMed
description BACKGROUND: Simultaneous reconstruction of emission and attenuation images in time-of-flight (TOF) positron emission tomography (PET) does not provide a unique solution. In this study, we propose to solve this limitation by including additional information given by a reference object with known attenuation placed outside the patient. Different configurations of the reference object were studied including geometry, material composition, and activity, and an optimal configuration was defined. In addition, this configuration was tested for different timing resolutions and noise levels. RESULTS: The proposed strategy was tested in 2D simulations obtained by forward projection of available PET/CT data and noise was included using Monte Carlo techniques. Obtained results suggest that the optimal configuration corresponds to a water cylinder inserted in the patient table and filled with activity. In that case, mean differences between reconstructed and true images were below 10%. However, better results can be obtained by increasing the activity of the reference object. CONCLUSION: This study shows promising results that might allow to obtain an accurate attenuation map from pure TOF-PET data without prior knowledge obtained from CT, MRI, or transmission scans.
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spelling pubmed-69575982020-01-27 Simultaneous emission and attenuation reconstruction in time-of-flight PET using a reference object García-Pérez, Pablo España, Samuel EJNMMI Phys Original Research BACKGROUND: Simultaneous reconstruction of emission and attenuation images in time-of-flight (TOF) positron emission tomography (PET) does not provide a unique solution. In this study, we propose to solve this limitation by including additional information given by a reference object with known attenuation placed outside the patient. Different configurations of the reference object were studied including geometry, material composition, and activity, and an optimal configuration was defined. In addition, this configuration was tested for different timing resolutions and noise levels. RESULTS: The proposed strategy was tested in 2D simulations obtained by forward projection of available PET/CT data and noise was included using Monte Carlo techniques. Obtained results suggest that the optimal configuration corresponds to a water cylinder inserted in the patient table and filled with activity. In that case, mean differences between reconstructed and true images were below 10%. However, better results can be obtained by increasing the activity of the reference object. CONCLUSION: This study shows promising results that might allow to obtain an accurate attenuation map from pure TOF-PET data without prior knowledge obtained from CT, MRI, or transmission scans. Springer International Publishing 2020-01-13 /pmc/articles/PMC6957598/ /pubmed/31932984 http://dx.doi.org/10.1186/s40658-020-0272-9 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
García-Pérez, Pablo
España, Samuel
Simultaneous emission and attenuation reconstruction in time-of-flight PET using a reference object
title Simultaneous emission and attenuation reconstruction in time-of-flight PET using a reference object
title_full Simultaneous emission and attenuation reconstruction in time-of-flight PET using a reference object
title_fullStr Simultaneous emission and attenuation reconstruction in time-of-flight PET using a reference object
title_full_unstemmed Simultaneous emission and attenuation reconstruction in time-of-flight PET using a reference object
title_short Simultaneous emission and attenuation reconstruction in time-of-flight PET using a reference object
title_sort simultaneous emission and attenuation reconstruction in time-of-flight pet using a reference object
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957598/
https://www.ncbi.nlm.nih.gov/pubmed/31932984
http://dx.doi.org/10.1186/s40658-020-0272-9
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