A Thyroid-stimulating Hormone (TSH) Producing Adenoma in a Patient with Severe Hypothyroidism: Thyroxine Replacement Reduced the TSH Level and Tumor Size

We treated an extremely rare thyroid-stimulating hormone (TSH)-producing pituitary adenoma in a 63-year-old woman with severe hypothyroidism due to autoimmune thyroiditis. She was presented with dizziness and fatigue. The blood level of TSH, prolactin, and fT4 was 288.2 μIU/mL, 72.9 ng/mL, and 0.24...

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Autores principales: Arimura, Hiroshi, Askoro, Rofat, Fujio, Shingo, Ummah, Fauziah C., Takajo, Tomoko, Nagano, Yushi, Nishio, Yoshihiko, Arita, Kazunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Neurosurgical Society 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957777/
https://www.ncbi.nlm.nih.gov/pubmed/31938677
http://dx.doi.org/10.2176/nmccrj.cr.2018-0323
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author Arimura, Hiroshi
Askoro, Rofat
Fujio, Shingo
Ummah, Fauziah C.
Takajo, Tomoko
Nagano, Yushi
Nishio, Yoshihiko
Arita, Kazunori
author_facet Arimura, Hiroshi
Askoro, Rofat
Fujio, Shingo
Ummah, Fauziah C.
Takajo, Tomoko
Nagano, Yushi
Nishio, Yoshihiko
Arita, Kazunori
author_sort Arimura, Hiroshi
collection PubMed
description We treated an extremely rare thyroid-stimulating hormone (TSH)-producing pituitary adenoma in a 63-year-old woman with severe hypothyroidism due to autoimmune thyroiditis. She was presented with dizziness and fatigue. The blood level of TSH, prolactin, and fT4 was 288.2 μIU/mL, 72.9 ng/mL, and 0.24 ng/dL, respectively. Magnetic resonance imaging demonstrated a large pituitary tumor, 31 mm in height, and a normal pituitary gland. Preoperative thyroxine replacement reduced the TSH level to 2.05 μIU/mL and produced a significant reduction in the tumor volume. Histopathologically, the surgically removed tumor was a TSH-producing pituitary adenoma.
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spelling pubmed-69577772020-01-14 A Thyroid-stimulating Hormone (TSH) Producing Adenoma in a Patient with Severe Hypothyroidism: Thyroxine Replacement Reduced the TSH Level and Tumor Size Arimura, Hiroshi Askoro, Rofat Fujio, Shingo Ummah, Fauziah C. Takajo, Tomoko Nagano, Yushi Nishio, Yoshihiko Arita, Kazunori NMC Case Rep J Case Report We treated an extremely rare thyroid-stimulating hormone (TSH)-producing pituitary adenoma in a 63-year-old woman with severe hypothyroidism due to autoimmune thyroiditis. She was presented with dizziness and fatigue. The blood level of TSH, prolactin, and fT4 was 288.2 μIU/mL, 72.9 ng/mL, and 0.24 ng/dL, respectively. Magnetic resonance imaging demonstrated a large pituitary tumor, 31 mm in height, and a normal pituitary gland. Preoperative thyroxine replacement reduced the TSH level to 2.05 μIU/mL and produced a significant reduction in the tumor volume. Histopathologically, the surgically removed tumor was a TSH-producing pituitary adenoma. The Japan Neurosurgical Society 2019-12-18 /pmc/articles/PMC6957777/ /pubmed/31938677 http://dx.doi.org/10.2176/nmccrj.cr.2018-0323 Text en © 2020 The Japan Neurosurgical Society This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Case Report
Arimura, Hiroshi
Askoro, Rofat
Fujio, Shingo
Ummah, Fauziah C.
Takajo, Tomoko
Nagano, Yushi
Nishio, Yoshihiko
Arita, Kazunori
A Thyroid-stimulating Hormone (TSH) Producing Adenoma in a Patient with Severe Hypothyroidism: Thyroxine Replacement Reduced the TSH Level and Tumor Size
title A Thyroid-stimulating Hormone (TSH) Producing Adenoma in a Patient with Severe Hypothyroidism: Thyroxine Replacement Reduced the TSH Level and Tumor Size
title_full A Thyroid-stimulating Hormone (TSH) Producing Adenoma in a Patient with Severe Hypothyroidism: Thyroxine Replacement Reduced the TSH Level and Tumor Size
title_fullStr A Thyroid-stimulating Hormone (TSH) Producing Adenoma in a Patient with Severe Hypothyroidism: Thyroxine Replacement Reduced the TSH Level and Tumor Size
title_full_unstemmed A Thyroid-stimulating Hormone (TSH) Producing Adenoma in a Patient with Severe Hypothyroidism: Thyroxine Replacement Reduced the TSH Level and Tumor Size
title_short A Thyroid-stimulating Hormone (TSH) Producing Adenoma in a Patient with Severe Hypothyroidism: Thyroxine Replacement Reduced the TSH Level and Tumor Size
title_sort thyroid-stimulating hormone (tsh) producing adenoma in a patient with severe hypothyroidism: thyroxine replacement reduced the tsh level and tumor size
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957777/
https://www.ncbi.nlm.nih.gov/pubmed/31938677
http://dx.doi.org/10.2176/nmccrj.cr.2018-0323
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