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Differences in early and late pattern-onset visual-evoked potentials between self- reported migraineurs and controls
Striped patterns have been shown to induce strong visual illusions and discomforts to migraineurs in previous literature. Previous research has suggested that these unusual visual symptoms to be linked with the hyperactivity on the visual cortex of migraine sufferers. The present study searched for...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957816/ https://www.ncbi.nlm.nih.gov/pubmed/31931401 http://dx.doi.org/10.1016/j.nicl.2019.102122 |
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author | Fong, Chun Yuen Law, Wai Him Crystal Braithwaite, Jason Mazaheri, Ali |
author_facet | Fong, Chun Yuen Law, Wai Him Crystal Braithwaite, Jason Mazaheri, Ali |
author_sort | Fong, Chun Yuen |
collection | PubMed |
description | Striped patterns have been shown to induce strong visual illusions and discomforts to migraineurs in previous literature. Previous research has suggested that these unusual visual symptoms to be linked with the hyperactivity on the visual cortex of migraine sufferers. The present study searched for evidence supporting this hypothesis by comparing the visual evoked potentials (VEPs) elicited by striped patterns of specific spatial frequencies (0.5, 3, and 13 cycles-per-degree) between a group of 29 migraineurs (17 with aura/12 without) and 31 non-migraineurs. In addition, VEPs to the same stripped patterns were compared between non-migraineurs who were classified as hyperexcitable versus non-hyperexcitable using a previously established behavioural pattern glare task. We found that the migraineurs had a significantly increased N2 amplitude for stimuli with 13 cpd gratings but an attenuated late negativity (LN: 400 – 500 ms after the stimuli onset) for all the spatial frequencies. Interestingly, non-migraineurs who scored as hyperexcitable appeared to have similar response patterns to the migraineurs, albeit in an attenuated form. We propose that the enhanced N2 could reflect disruption of the balance between parvocellular and magnocellular pathway, which is in support of the cortical hyperexcitation hypothesis in migraineurs. In addition, the attenuation of the late negativity could reflect a top-down feedback mechanism to suppress visual processing of an aversive stimulus. |
format | Online Article Text |
id | pubmed-6957816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-69578162020-01-17 Differences in early and late pattern-onset visual-evoked potentials between self- reported migraineurs and controls Fong, Chun Yuen Law, Wai Him Crystal Braithwaite, Jason Mazaheri, Ali Neuroimage Clin Regular Article Striped patterns have been shown to induce strong visual illusions and discomforts to migraineurs in previous literature. Previous research has suggested that these unusual visual symptoms to be linked with the hyperactivity on the visual cortex of migraine sufferers. The present study searched for evidence supporting this hypothesis by comparing the visual evoked potentials (VEPs) elicited by striped patterns of specific spatial frequencies (0.5, 3, and 13 cycles-per-degree) between a group of 29 migraineurs (17 with aura/12 without) and 31 non-migraineurs. In addition, VEPs to the same stripped patterns were compared between non-migraineurs who were classified as hyperexcitable versus non-hyperexcitable using a previously established behavioural pattern glare task. We found that the migraineurs had a significantly increased N2 amplitude for stimuli with 13 cpd gratings but an attenuated late negativity (LN: 400 – 500 ms after the stimuli onset) for all the spatial frequencies. Interestingly, non-migraineurs who scored as hyperexcitable appeared to have similar response patterns to the migraineurs, albeit in an attenuated form. We propose that the enhanced N2 could reflect disruption of the balance between parvocellular and magnocellular pathway, which is in support of the cortical hyperexcitation hypothesis in migraineurs. In addition, the attenuation of the late negativity could reflect a top-down feedback mechanism to suppress visual processing of an aversive stimulus. Elsevier 2019-12-16 /pmc/articles/PMC6957816/ /pubmed/31931401 http://dx.doi.org/10.1016/j.nicl.2019.102122 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Fong, Chun Yuen Law, Wai Him Crystal Braithwaite, Jason Mazaheri, Ali Differences in early and late pattern-onset visual-evoked potentials between self- reported migraineurs and controls |
title | Differences in early and late pattern-onset visual-evoked potentials between self- reported migraineurs and controls |
title_full | Differences in early and late pattern-onset visual-evoked potentials between self- reported migraineurs and controls |
title_fullStr | Differences in early and late pattern-onset visual-evoked potentials between self- reported migraineurs and controls |
title_full_unstemmed | Differences in early and late pattern-onset visual-evoked potentials between self- reported migraineurs and controls |
title_short | Differences in early and late pattern-onset visual-evoked potentials between self- reported migraineurs and controls |
title_sort | differences in early and late pattern-onset visual-evoked potentials between self- reported migraineurs and controls |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957816/ https://www.ncbi.nlm.nih.gov/pubmed/31931401 http://dx.doi.org/10.1016/j.nicl.2019.102122 |
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