RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation

BACKGROUND AND AIMS: Tumor necrosis factor (TNF) is a major pathogenic effector and a therapeutic target in inflammatory bowel disease (IBD), yet the basis for TNF-induced intestinal epithelial cell (IEC) death is unknown, because TNF does not kill normal IECs. Here, we investigated how chronic nucl...

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Detalles Bibliográficos
Autores principales: Wong, Jerry, Garcia-Carbonell, Ricard, Zelic, Matija, Ho, Samuel B., Boland, Brigid S., Yao, Shih-Jing, Desai, Shalin A., Das, Soumita, Planell, Núria, Harris, Philip A., Font-Burgada, Joan, Taniguchi, Koji, Bertin, John, Salas, Azucena, Pasparakis, Manolis, Gough, Pete J., Kelliher, Michelle, Karin, Michael, Guma, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957844/
https://www.ncbi.nlm.nih.gov/pubmed/31606566
http://dx.doi.org/10.1016/j.jcmgh.2019.10.002

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