Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant

Spinal muscular atrophy (SMA) is a devastating motor neuron disorder caused by mutations in the survival motor neuron (SMN) gene. It remains unclear how SMN deficiency leads to the loss of motor neurons. By screening Schizosaccharomyces pombe, we found that the growth defect of an SMN mutant can be...

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Detalles Bibliográficos
Autores principales: Antoine, Marie, Patrick, Kristin L., Soret, Johann, Duc, Pauline, Rage, Florence, Cacciottolo, Rebecca, Nissen, Kelly E., Cauchi, Ruben J., Krogan, Nevan J., Guthrie, Christine, Gachet, Yannick, Bordonné, Rémy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957872/
https://www.ncbi.nlm.nih.gov/pubmed/31927482
http://dx.doi.org/10.1016/j.isci.2019.100809

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