Cargando…

Lipid-Assisted Polymerization of Nucleotides

In addition to being one of the proponents of the “Lipid World hypothesis”, David Deamer, together with other colleagues, pioneered studies involving formation of RNA-like oligomers from their ‘non-activated’, prebiotically plausible monomeric moieties. In particular, the pioneering work in this reg...

Descripción completa

Detalles Bibliográficos
Autores principales: Olasagasti, Felix, Rajamani, Sudha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958317/
https://www.ncbi.nlm.nih.gov/pubmed/31694196
http://dx.doi.org/10.3390/life9040083
_version_ 1783487385714032640
author Olasagasti, Felix
Rajamani, Sudha
author_facet Olasagasti, Felix
Rajamani, Sudha
author_sort Olasagasti, Felix
collection PubMed
description In addition to being one of the proponents of the “Lipid World hypothesis”, David Deamer, together with other colleagues, pioneered studies involving formation of RNA-like oligomers from their ‘non-activated’, prebiotically plausible monomeric moieties. In particular, the pioneering work in this regard was a publication from 2008 in Origins of Life and Evolution of Biospheres, The Journal of the International Astrobiology Society, wherein we described the formation of RNA-like oligomers from nucleoside 5’-monophosphates. In that study, we had simulated a terrestrial geothermal environment, a niche that is thought to have facilitated the prebiotic non-enzymatic synthesis of polynucleotides. We showed that a mixture of lipids and non-activated mononucleotides resulted in the formation of relatively long strands of RNA-like polymers when subjected to repeated cycles of dehydration and rehydration (DH-RH). Since 2008, terrestrial geothermal niches and DH-RH conditions have been explored in the context of several other prebiotic processes. In this article, we review the work that we and other researchers have carried out since then in this line of research, including the development of new apparatus to carry out the simulation of prebiotic terrestrial geothermal environments.
format Online
Article
Text
id pubmed-6958317
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69583172020-01-23 Lipid-Assisted Polymerization of Nucleotides Olasagasti, Felix Rajamani, Sudha Life (Basel) Review In addition to being one of the proponents of the “Lipid World hypothesis”, David Deamer, together with other colleagues, pioneered studies involving formation of RNA-like oligomers from their ‘non-activated’, prebiotically plausible monomeric moieties. In particular, the pioneering work in this regard was a publication from 2008 in Origins of Life and Evolution of Biospheres, The Journal of the International Astrobiology Society, wherein we described the formation of RNA-like oligomers from nucleoside 5’-monophosphates. In that study, we had simulated a terrestrial geothermal environment, a niche that is thought to have facilitated the prebiotic non-enzymatic synthesis of polynucleotides. We showed that a mixture of lipids and non-activated mononucleotides resulted in the formation of relatively long strands of RNA-like polymers when subjected to repeated cycles of dehydration and rehydration (DH-RH). Since 2008, terrestrial geothermal niches and DH-RH conditions have been explored in the context of several other prebiotic processes. In this article, we review the work that we and other researchers have carried out since then in this line of research, including the development of new apparatus to carry out the simulation of prebiotic terrestrial geothermal environments. MDPI 2019-11-05 /pmc/articles/PMC6958317/ /pubmed/31694196 http://dx.doi.org/10.3390/life9040083 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Olasagasti, Felix
Rajamani, Sudha
Lipid-Assisted Polymerization of Nucleotides
title Lipid-Assisted Polymerization of Nucleotides
title_full Lipid-Assisted Polymerization of Nucleotides
title_fullStr Lipid-Assisted Polymerization of Nucleotides
title_full_unstemmed Lipid-Assisted Polymerization of Nucleotides
title_short Lipid-Assisted Polymerization of Nucleotides
title_sort lipid-assisted polymerization of nucleotides
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958317/
https://www.ncbi.nlm.nih.gov/pubmed/31694196
http://dx.doi.org/10.3390/life9040083
work_keys_str_mv AT olasagastifelix lipidassistedpolymerizationofnucleotides
AT rajamanisudha lipidassistedpolymerizationofnucleotides