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Lipid-Assisted Polymerization of Nucleotides
In addition to being one of the proponents of the “Lipid World hypothesis”, David Deamer, together with other colleagues, pioneered studies involving formation of RNA-like oligomers from their ‘non-activated’, prebiotically plausible monomeric moieties. In particular, the pioneering work in this reg...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958317/ https://www.ncbi.nlm.nih.gov/pubmed/31694196 http://dx.doi.org/10.3390/life9040083 |
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author | Olasagasti, Felix Rajamani, Sudha |
author_facet | Olasagasti, Felix Rajamani, Sudha |
author_sort | Olasagasti, Felix |
collection | PubMed |
description | In addition to being one of the proponents of the “Lipid World hypothesis”, David Deamer, together with other colleagues, pioneered studies involving formation of RNA-like oligomers from their ‘non-activated’, prebiotically plausible monomeric moieties. In particular, the pioneering work in this regard was a publication from 2008 in Origins of Life and Evolution of Biospheres, The Journal of the International Astrobiology Society, wherein we described the formation of RNA-like oligomers from nucleoside 5’-monophosphates. In that study, we had simulated a terrestrial geothermal environment, a niche that is thought to have facilitated the prebiotic non-enzymatic synthesis of polynucleotides. We showed that a mixture of lipids and non-activated mononucleotides resulted in the formation of relatively long strands of RNA-like polymers when subjected to repeated cycles of dehydration and rehydration (DH-RH). Since 2008, terrestrial geothermal niches and DH-RH conditions have been explored in the context of several other prebiotic processes. In this article, we review the work that we and other researchers have carried out since then in this line of research, including the development of new apparatus to carry out the simulation of prebiotic terrestrial geothermal environments. |
format | Online Article Text |
id | pubmed-6958317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69583172020-01-23 Lipid-Assisted Polymerization of Nucleotides Olasagasti, Felix Rajamani, Sudha Life (Basel) Review In addition to being one of the proponents of the “Lipid World hypothesis”, David Deamer, together with other colleagues, pioneered studies involving formation of RNA-like oligomers from their ‘non-activated’, prebiotically plausible monomeric moieties. In particular, the pioneering work in this regard was a publication from 2008 in Origins of Life and Evolution of Biospheres, The Journal of the International Astrobiology Society, wherein we described the formation of RNA-like oligomers from nucleoside 5’-monophosphates. In that study, we had simulated a terrestrial geothermal environment, a niche that is thought to have facilitated the prebiotic non-enzymatic synthesis of polynucleotides. We showed that a mixture of lipids and non-activated mononucleotides resulted in the formation of relatively long strands of RNA-like polymers when subjected to repeated cycles of dehydration and rehydration (DH-RH). Since 2008, terrestrial geothermal niches and DH-RH conditions have been explored in the context of several other prebiotic processes. In this article, we review the work that we and other researchers have carried out since then in this line of research, including the development of new apparatus to carry out the simulation of prebiotic terrestrial geothermal environments. MDPI 2019-11-05 /pmc/articles/PMC6958317/ /pubmed/31694196 http://dx.doi.org/10.3390/life9040083 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Olasagasti, Felix Rajamani, Sudha Lipid-Assisted Polymerization of Nucleotides |
title | Lipid-Assisted Polymerization of Nucleotides |
title_full | Lipid-Assisted Polymerization of Nucleotides |
title_fullStr | Lipid-Assisted Polymerization of Nucleotides |
title_full_unstemmed | Lipid-Assisted Polymerization of Nucleotides |
title_short | Lipid-Assisted Polymerization of Nucleotides |
title_sort | lipid-assisted polymerization of nucleotides |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958317/ https://www.ncbi.nlm.nih.gov/pubmed/31694196 http://dx.doi.org/10.3390/life9040083 |
work_keys_str_mv | AT olasagastifelix lipidassistedpolymerizationofnucleotides AT rajamanisudha lipidassistedpolymerizationofnucleotides |