Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment

Conventional chemotherapy regimens have limitations due to serious adverse effects. Targeted drug delivery systems to reduce systemic toxicity are a powerful drug development platform. Encapsulation of antitumor drug(s) in thermosensitive nanocarriers is an emerging approach with a promise to improv...

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Detalles Bibliográficos
Autores principales: Pereira Gomes, Isabela, Aparecida Duarte, Jaqueline, Chaves Maia, Ana Luiza, Rubello, Domenico, Townsend, Danyelle M., Branco de Barros, André Luís, Leite, Elaine Amaral
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958340/
https://www.ncbi.nlm.nih.gov/pubmed/31775273
http://dx.doi.org/10.3390/ph12040171
Descripción
Sumario:Conventional chemotherapy regimens have limitations due to serious adverse effects. Targeted drug delivery systems to reduce systemic toxicity are a powerful drug development platform. Encapsulation of antitumor drug(s) in thermosensitive nanocarriers is an emerging approach with a promise to improve uptake and increase therapeutic efficacy, as they can be activated by hyperthermia selectively at the tumor site. In this review, we focus on thermosensitive nanosystems associated with hyperthermia for the treatment of cancer, in preclinical and clinical use.

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