Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment

Conventional chemotherapy regimens have limitations due to serious adverse effects. Targeted drug delivery systems to reduce systemic toxicity are a powerful drug development platform. Encapsulation of antitumor drug(s) in thermosensitive nanocarriers is an emerging approach with a promise to improv...

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Autores principales: Pereira Gomes, Isabela, Aparecida Duarte, Jaqueline, Chaves Maia, Ana Luiza, Rubello, Domenico, Townsend, Danyelle M., Branco de Barros, André Luís, Leite, Elaine Amaral
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958340/
https://www.ncbi.nlm.nih.gov/pubmed/31775273
http://dx.doi.org/10.3390/ph12040171
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author Pereira Gomes, Isabela
Aparecida Duarte, Jaqueline
Chaves Maia, Ana Luiza
Rubello, Domenico
Townsend, Danyelle M.
Branco de Barros, André Luís
Leite, Elaine Amaral
author_facet Pereira Gomes, Isabela
Aparecida Duarte, Jaqueline
Chaves Maia, Ana Luiza
Rubello, Domenico
Townsend, Danyelle M.
Branco de Barros, André Luís
Leite, Elaine Amaral
author_sort Pereira Gomes, Isabela
collection PubMed
description Conventional chemotherapy regimens have limitations due to serious adverse effects. Targeted drug delivery systems to reduce systemic toxicity are a powerful drug development platform. Encapsulation of antitumor drug(s) in thermosensitive nanocarriers is an emerging approach with a promise to improve uptake and increase therapeutic efficacy, as they can be activated by hyperthermia selectively at the tumor site. In this review, we focus on thermosensitive nanosystems associated with hyperthermia for the treatment of cancer, in preclinical and clinical use.
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spelling pubmed-69583402020-01-23 Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment Pereira Gomes, Isabela Aparecida Duarte, Jaqueline Chaves Maia, Ana Luiza Rubello, Domenico Townsend, Danyelle M. Branco de Barros, André Luís Leite, Elaine Amaral Pharmaceuticals (Basel) Review Conventional chemotherapy regimens have limitations due to serious adverse effects. Targeted drug delivery systems to reduce systemic toxicity are a powerful drug development platform. Encapsulation of antitumor drug(s) in thermosensitive nanocarriers is an emerging approach with a promise to improve uptake and increase therapeutic efficacy, as they can be activated by hyperthermia selectively at the tumor site. In this review, we focus on thermosensitive nanosystems associated with hyperthermia for the treatment of cancer, in preclinical and clinical use. MDPI 2019-11-25 /pmc/articles/PMC6958340/ /pubmed/31775273 http://dx.doi.org/10.3390/ph12040171 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pereira Gomes, Isabela
Aparecida Duarte, Jaqueline
Chaves Maia, Ana Luiza
Rubello, Domenico
Townsend, Danyelle M.
Branco de Barros, André Luís
Leite, Elaine Amaral
Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment
title Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment
title_full Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment
title_fullStr Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment
title_full_unstemmed Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment
title_short Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment
title_sort thermosensitive nanosystems associated with hyperthermia for cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958340/
https://www.ncbi.nlm.nih.gov/pubmed/31775273
http://dx.doi.org/10.3390/ph12040171
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