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Neural Predictors of the Antidepressant Placebo Response
The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates. This manuscript reviews recent neuroimaging studies that aim to identify the neural signature of an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958379/ https://www.ncbi.nlm.nih.gov/pubmed/31635043 http://dx.doi.org/10.3390/ph12040158 |
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author | Rette, Danielle McDonald, Erin Iosifescu, Dan V. Collins, Katherine A. |
author_facet | Rette, Danielle McDonald, Erin Iosifescu, Dan V. Collins, Katherine A. |
author_sort | Rette, Danielle |
collection | PubMed |
description | The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates. This manuscript reviews recent neuroimaging studies that aim to identify the neural signature of antidepressant placebo response. Data captured in clinical trials have primarily focused on antidepressant efficacy or predicting antidepressant response and have reliably implicated the rostral anterior cingulate cortex (rACC) in antidepressant placebo response, but also in medication response. Imaging and electroencephalography (EEG) experiments specifically interrogating the mechanism of antidepressant placebo response, while few, suggest the reward network, including opiate neurotransmission, is also involved. Therefore, while the rACC is likely involved in the antidepressant placebo response, its observation in isolation is unlikely to prospectively distinguish antidepressant placebo from medication responders. Instead, future studies of antidepressant placebo response should probe the reward network as a whole and incorporate sophisticated computational analytical approaches. |
format | Online Article Text |
id | pubmed-6958379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69583792020-01-23 Neural Predictors of the Antidepressant Placebo Response Rette, Danielle McDonald, Erin Iosifescu, Dan V. Collins, Katherine A. Pharmaceuticals (Basel) Review The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates. This manuscript reviews recent neuroimaging studies that aim to identify the neural signature of antidepressant placebo response. Data captured in clinical trials have primarily focused on antidepressant efficacy or predicting antidepressant response and have reliably implicated the rostral anterior cingulate cortex (rACC) in antidepressant placebo response, but also in medication response. Imaging and electroencephalography (EEG) experiments specifically interrogating the mechanism of antidepressant placebo response, while few, suggest the reward network, including opiate neurotransmission, is also involved. Therefore, while the rACC is likely involved in the antidepressant placebo response, its observation in isolation is unlikely to prospectively distinguish antidepressant placebo from medication responders. Instead, future studies of antidepressant placebo response should probe the reward network as a whole and incorporate sophisticated computational analytical approaches. MDPI 2019-10-19 /pmc/articles/PMC6958379/ /pubmed/31635043 http://dx.doi.org/10.3390/ph12040158 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rette, Danielle McDonald, Erin Iosifescu, Dan V. Collins, Katherine A. Neural Predictors of the Antidepressant Placebo Response |
title | Neural Predictors of the Antidepressant Placebo Response |
title_full | Neural Predictors of the Antidepressant Placebo Response |
title_fullStr | Neural Predictors of the Antidepressant Placebo Response |
title_full_unstemmed | Neural Predictors of the Antidepressant Placebo Response |
title_short | Neural Predictors of the Antidepressant Placebo Response |
title_sort | neural predictors of the antidepressant placebo response |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958379/ https://www.ncbi.nlm.nih.gov/pubmed/31635043 http://dx.doi.org/10.3390/ph12040158 |
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