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Neural Predictors of the Antidepressant Placebo Response

The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates. This manuscript reviews recent neuroimaging studies that aim to identify the neural signature of an...

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Detalles Bibliográficos
Autores principales: Rette, Danielle, McDonald, Erin, Iosifescu, Dan V., Collins, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958379/
https://www.ncbi.nlm.nih.gov/pubmed/31635043
http://dx.doi.org/10.3390/ph12040158
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author Rette, Danielle
McDonald, Erin
Iosifescu, Dan V.
Collins, Katherine A.
author_facet Rette, Danielle
McDonald, Erin
Iosifescu, Dan V.
Collins, Katherine A.
author_sort Rette, Danielle
collection PubMed
description The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates. This manuscript reviews recent neuroimaging studies that aim to identify the neural signature of antidepressant placebo response. Data captured in clinical trials have primarily focused on antidepressant efficacy or predicting antidepressant response and have reliably implicated the rostral anterior cingulate cortex (rACC) in antidepressant placebo response, but also in medication response. Imaging and electroencephalography (EEG) experiments specifically interrogating the mechanism of antidepressant placebo response, while few, suggest the reward network, including opiate neurotransmission, is also involved. Therefore, while the rACC is likely involved in the antidepressant placebo response, its observation in isolation is unlikely to prospectively distinguish antidepressant placebo from medication responders. Instead, future studies of antidepressant placebo response should probe the reward network as a whole and incorporate sophisticated computational analytical approaches.
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spelling pubmed-69583792020-01-23 Neural Predictors of the Antidepressant Placebo Response Rette, Danielle McDonald, Erin Iosifescu, Dan V. Collins, Katherine A. Pharmaceuticals (Basel) Review The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates. This manuscript reviews recent neuroimaging studies that aim to identify the neural signature of antidepressant placebo response. Data captured in clinical trials have primarily focused on antidepressant efficacy or predicting antidepressant response and have reliably implicated the rostral anterior cingulate cortex (rACC) in antidepressant placebo response, but also in medication response. Imaging and electroencephalography (EEG) experiments specifically interrogating the mechanism of antidepressant placebo response, while few, suggest the reward network, including opiate neurotransmission, is also involved. Therefore, while the rACC is likely involved in the antidepressant placebo response, its observation in isolation is unlikely to prospectively distinguish antidepressant placebo from medication responders. Instead, future studies of antidepressant placebo response should probe the reward network as a whole and incorporate sophisticated computational analytical approaches. MDPI 2019-10-19 /pmc/articles/PMC6958379/ /pubmed/31635043 http://dx.doi.org/10.3390/ph12040158 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rette, Danielle
McDonald, Erin
Iosifescu, Dan V.
Collins, Katherine A.
Neural Predictors of the Antidepressant Placebo Response
title Neural Predictors of the Antidepressant Placebo Response
title_full Neural Predictors of the Antidepressant Placebo Response
title_fullStr Neural Predictors of the Antidepressant Placebo Response
title_full_unstemmed Neural Predictors of the Antidepressant Placebo Response
title_short Neural Predictors of the Antidepressant Placebo Response
title_sort neural predictors of the antidepressant placebo response
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958379/
https://www.ncbi.nlm.nih.gov/pubmed/31635043
http://dx.doi.org/10.3390/ph12040158
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