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Cryptosporidiosis among Hemodialysis Patients in Jordan: First Preliminary Screening Surveillance

Few studies have reported the incidence of cryptosporidiosis among hemodialysis patients worldwide. Currently many molecular and immunological assays have been developed for the sensitive diagnosis of cryptosporidiosis, but still, the microscopic detection of the parasitic infective stage (oocysts)...

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Autores principales: Zueter, AbdelRahman M., Hijjawi, Nawal S., Hamadeneh, Khaled N., Al-Sheyab, Maysa M., Hatamleh, Amal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958476/
https://www.ncbi.nlm.nih.gov/pubmed/31635249
http://dx.doi.org/10.3390/tropicalmed4040131
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author Zueter, AbdelRahman M.
Hijjawi, Nawal S.
Hamadeneh, Khaled N.
Al-Sheyab, Maysa M.
Hatamleh, Amal M.
author_facet Zueter, AbdelRahman M.
Hijjawi, Nawal S.
Hamadeneh, Khaled N.
Al-Sheyab, Maysa M.
Hatamleh, Amal M.
author_sort Zueter, AbdelRahman M.
collection PubMed
description Few studies have reported the incidence of cryptosporidiosis among hemodialysis patients worldwide. Currently many molecular and immunological assays have been developed for the sensitive diagnosis of cryptosporidiosis, but still, the microscopic detection of the parasitic infective stage (oocysts) in stool specimens using modified acid stain is regarded as a reliable sensitive technique which is widely used in many clinical labs. In the present study, a total of 133 stool samples were collected from hemodialysis patients and were screened for Cryptosporidium oocyst using formalin-ether concentration and modified acid-fast staining technique. Clinical and demographic data were also collected and analyzed. Cryptosporidium oocysts were recovered in 15/133 (11%) of the investigated hemodialysis patients. The age of patients ranged from 25 to 80 years (mean: 57.84 ± 12.22). Most of the Cryptosporidium-positive cases were recovered from males (73.7%) residing in rural villages in Irbid city (86.6%). The most repeatedly reported symptoms in the Cryptosporidium-positive patients were gastrointestinal symptoms, including diarrhea (15%), nausea (24%), abdominal pain (23%) and bloating (17%), in addition to general fatigue (32%) and weight loss (19%). No statistically significant associations for certain clinical symptoms or risk factors were found. The present study is the first preliminary study in Jordan that provided a brief screening for the incidence of cryptosporidiosis among hemodialysis patients.
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spelling pubmed-69584762020-01-23 Cryptosporidiosis among Hemodialysis Patients in Jordan: First Preliminary Screening Surveillance Zueter, AbdelRahman M. Hijjawi, Nawal S. Hamadeneh, Khaled N. Al-Sheyab, Maysa M. Hatamleh, Amal M. Trop Med Infect Dis Article Few studies have reported the incidence of cryptosporidiosis among hemodialysis patients worldwide. Currently many molecular and immunological assays have been developed for the sensitive diagnosis of cryptosporidiosis, but still, the microscopic detection of the parasitic infective stage (oocysts) in stool specimens using modified acid stain is regarded as a reliable sensitive technique which is widely used in many clinical labs. In the present study, a total of 133 stool samples were collected from hemodialysis patients and were screened for Cryptosporidium oocyst using formalin-ether concentration and modified acid-fast staining technique. Clinical and demographic data were also collected and analyzed. Cryptosporidium oocysts were recovered in 15/133 (11%) of the investigated hemodialysis patients. The age of patients ranged from 25 to 80 years (mean: 57.84 ± 12.22). Most of the Cryptosporidium-positive cases were recovered from males (73.7%) residing in rural villages in Irbid city (86.6%). The most repeatedly reported symptoms in the Cryptosporidium-positive patients were gastrointestinal symptoms, including diarrhea (15%), nausea (24%), abdominal pain (23%) and bloating (17%), in addition to general fatigue (32%) and weight loss (19%). No statistically significant associations for certain clinical symptoms or risk factors were found. The present study is the first preliminary study in Jordan that provided a brief screening for the incidence of cryptosporidiosis among hemodialysis patients. MDPI 2019-10-18 /pmc/articles/PMC6958476/ /pubmed/31635249 http://dx.doi.org/10.3390/tropicalmed4040131 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zueter, AbdelRahman M.
Hijjawi, Nawal S.
Hamadeneh, Khaled N.
Al-Sheyab, Maysa M.
Hatamleh, Amal M.
Cryptosporidiosis among Hemodialysis Patients in Jordan: First Preliminary Screening Surveillance
title Cryptosporidiosis among Hemodialysis Patients in Jordan: First Preliminary Screening Surveillance
title_full Cryptosporidiosis among Hemodialysis Patients in Jordan: First Preliminary Screening Surveillance
title_fullStr Cryptosporidiosis among Hemodialysis Patients in Jordan: First Preliminary Screening Surveillance
title_full_unstemmed Cryptosporidiosis among Hemodialysis Patients in Jordan: First Preliminary Screening Surveillance
title_short Cryptosporidiosis among Hemodialysis Patients in Jordan: First Preliminary Screening Surveillance
title_sort cryptosporidiosis among hemodialysis patients in jordan: first preliminary screening surveillance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958476/
https://www.ncbi.nlm.nih.gov/pubmed/31635249
http://dx.doi.org/10.3390/tropicalmed4040131
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