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Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus
BACKGROUND: Paternal allele-specific DNA methylation of the H19 imprinting control region (ICR) regulates imprinted expression of the Igf2/H19 genes. The molecular mechanism by which differential methylation of the H19 ICR is established during gametogenesis and maintained after fertilization, howev...
Autores principales: | Matsuzaki, Hitomi, Kuramochi, Daichi, Okamura, Eiichi, Hirakawa, Katsuhiko, Ushiki, Aki, Tanimoto, Keiji |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958606/ https://www.ncbi.nlm.nih.gov/pubmed/31937365 http://dx.doi.org/10.1186/s13072-019-0326-1 |
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