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DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing—a possible predictive biomarker for malignant transformation

BACKGROUND: DNA hypermethylation of tumor suppressor genes is observed in precancerous lesions and oral cancer of individuals with the habits of betel quid (BQ) chewing. SIRT1 has been identified as playing a role in the maintenance of epithelial integrity, and its alteration is often related to car...

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Detalles Bibliográficos
Autores principales:	Islam, Shajedul, Uehara, Osamu, Matsuoka, Hirofumi, Kuramitsu, Yasuhiro, Adhikari, Bhoj Raj, Hiraki, Daichi, Toraya, Seiko, Jayawardena, Asiri, Saito, Ichiro, Muthumala, Malsantha, Nagayasu, Hiroki, Abiko, Yoshihiro, Chiba, Itsuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958620/ https://www.ncbi.nlm.nih.gov/pubmed/31931863 http://dx.doi.org/10.1186/s13148-019-0806-y

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