Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer’s-like mice

BACKGROUND: Pyroglutamate-3 Aβ (pGlu-3 Aβ) is an N-terminally truncated and post-translationally modified Aβ species found in Alzheimer’s disease (AD) brain. Its increased peptide aggregation propensity and toxicity make it an attractive emerging treatment strategy for AD. We address the question of...

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Detalles Bibliográficos
Autores principales: Crehan, Helen, Liu, Bin, Kleinschmidt, Martin, Rahfeld, Jens-Ulrich, Le, Kevin X., Caldarone, Barbara J., Frost, Jeffrey L., Hettmann, Thore, Hutter-Paier, Birgit, O’Nuallain, Brian, Park, Mi-Ae, DiCarli, Marcelo F., Lues, Inge, Schilling, Stephan, Lemere, Cynthia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958628/
https://www.ncbi.nlm.nih.gov/pubmed/31931873
http://dx.doi.org/10.1186/s13195-019-0579-8

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