Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption

There is no guideline concerning choice of antiretroviral therapy (ART) for HIV-infected patients after unplanned interruption. We conducted a retrospective cohort study of HIV-infected patients reintroduced to first-line ART after having unplanned interruption for at least 1 month. Viral load was e...

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Detalles Bibliográficos
Autores principales: Maria, Suzy, Yunihastuti, Evy, Saldi, Siti Rizny F., Djoerban, Zubairi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958649/
https://www.ncbi.nlm.nih.gov/pubmed/31928123
http://dx.doi.org/10.1177/2325958219899534
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author Maria, Suzy
Yunihastuti, Evy
Saldi, Siti Rizny F.
Djoerban, Zubairi
author_facet Maria, Suzy
Yunihastuti, Evy
Saldi, Siti Rizny F.
Djoerban, Zubairi
author_sort Maria, Suzy
collection PubMed
description There is no guideline concerning choice of antiretroviral therapy (ART) for HIV-infected patients after unplanned interruption. We conducted a retrospective cohort study of HIV-infected patients reintroduced to first-line ART after having unplanned interruption for at least 1 month. Viral load was evaluated at 6 to 18 months after the reintroduction. There were 100 patients included in our study, and 55 of them achieved virological success. History of single interruption (adjusted odds ratio [aOR] 5.51%, 95% confidence interval [CI] 1.82-16.68, P = .003) and CD4 count ≥200 cell/mm(3) at the time of reintroduction (aOR 4.33, 95% CI 1.14-16.39, P = .031) increased likelihood to achieve virological success.
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spelling pubmed-69586492020-01-23 Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption Maria, Suzy Yunihastuti, Evy Saldi, Siti Rizny F. Djoerban, Zubairi J Int Assoc Provid AIDS Care Short Communication There is no guideline concerning choice of antiretroviral therapy (ART) for HIV-infected patients after unplanned interruption. We conducted a retrospective cohort study of HIV-infected patients reintroduced to first-line ART after having unplanned interruption for at least 1 month. Viral load was evaluated at 6 to 18 months after the reintroduction. There were 100 patients included in our study, and 55 of them achieved virological success. History of single interruption (adjusted odds ratio [aOR] 5.51%, 95% confidence interval [CI] 1.82-16.68, P = .003) and CD4 count ≥200 cell/mm(3) at the time of reintroduction (aOR 4.33, 95% CI 1.14-16.39, P = .031) increased likelihood to achieve virological success. SAGE Publications 2020-01-13 /pmc/articles/PMC6958649/ /pubmed/31928123 http://dx.doi.org/10.1177/2325958219899534 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Short Communication
Maria, Suzy
Yunihastuti, Evy
Saldi, Siti Rizny F.
Djoerban, Zubairi
Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption
title Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption
title_full Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption
title_fullStr Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption
title_full_unstemmed Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption
title_short Factors Affecting Virological Outcome When First-Line Antiretroviral Therapy Is Reintroduced After Unplanned Interruption
title_sort factors affecting virological outcome when first-line antiretroviral therapy is reintroduced after unplanned interruption
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958649/
https://www.ncbi.nlm.nih.gov/pubmed/31928123
http://dx.doi.org/10.1177/2325958219899534
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