Change in plasma concentration of clozapine and norclozapine following a switch of oral formulation

BACKGROUND: Clozapine formulation has been shown to affect plasma concentrations of clozapine and norclozapine. Changes in formulation might result in toxicity or treatment failure. METHODS: We identified, from electronic records, patients who switched from clozapine tablets to oral liquid or vice v...

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Detalles Bibliográficos
Autores principales: Keshavarzi, Farinaz, Fox, Tony, Whiskey, Eromona, Taylor, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958650/
https://www.ncbi.nlm.nih.gov/pubmed/31976069
http://dx.doi.org/10.1177/2045125319899263
Descripción
Sumario:BACKGROUND: Clozapine formulation has been shown to affect plasma concentrations of clozapine and norclozapine. Changes in formulation might result in toxicity or treatment failure. METHODS: We identified, from electronic records, patients who switched from clozapine tablets to oral liquid or vice versa and compared plasma concentrations before and after the switch. RESULTS: We identified 13 patients with 85 blood samples who changed formulation of clozapine. Overall mean standardized clozapine plasma level was 0.67 mg/l daily dose on liquid and 0.87 mg/l daily dose on tablets (p = 0.035). CONCLUSION: Use of clozapine liquid results in lower plasma clozapine concentration than the same dose of tablets.

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