Change in plasma concentration of clozapine and norclozapine following a switch of oral formulation

BACKGROUND: Clozapine formulation has been shown to affect plasma concentrations of clozapine and norclozapine. Changes in formulation might result in toxicity or treatment failure. METHODS: We identified, from electronic records, patients who switched from clozapine tablets to oral liquid or vice v...

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Autores principales: Keshavarzi, Farinaz, Fox, Tony, Whiskey, Eromona, Taylor, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958650/
https://www.ncbi.nlm.nih.gov/pubmed/31976069
http://dx.doi.org/10.1177/2045125319899263
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author Keshavarzi, Farinaz
Fox, Tony
Whiskey, Eromona
Taylor, David
author_facet Keshavarzi, Farinaz
Fox, Tony
Whiskey, Eromona
Taylor, David
author_sort Keshavarzi, Farinaz
collection PubMed
description BACKGROUND: Clozapine formulation has been shown to affect plasma concentrations of clozapine and norclozapine. Changes in formulation might result in toxicity or treatment failure. METHODS: We identified, from electronic records, patients who switched from clozapine tablets to oral liquid or vice versa and compared plasma concentrations before and after the switch. RESULTS: We identified 13 patients with 85 blood samples who changed formulation of clozapine. Overall mean standardized clozapine plasma level was 0.67 mg/l daily dose on liquid and 0.87 mg/l daily dose on tablets (p = 0.035). CONCLUSION: Use of clozapine liquid results in lower plasma clozapine concentration than the same dose of tablets.
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spelling pubmed-69586502020-01-23 Change in plasma concentration of clozapine and norclozapine following a switch of oral formulation Keshavarzi, Farinaz Fox, Tony Whiskey, Eromona Taylor, David Ther Adv Psychopharmacol Original Research BACKGROUND: Clozapine formulation has been shown to affect plasma concentrations of clozapine and norclozapine. Changes in formulation might result in toxicity or treatment failure. METHODS: We identified, from electronic records, patients who switched from clozapine tablets to oral liquid or vice versa and compared plasma concentrations before and after the switch. RESULTS: We identified 13 patients with 85 blood samples who changed formulation of clozapine. Overall mean standardized clozapine plasma level was 0.67 mg/l daily dose on liquid and 0.87 mg/l daily dose on tablets (p = 0.035). CONCLUSION: Use of clozapine liquid results in lower plasma clozapine concentration than the same dose of tablets. SAGE Publications 2020-01-13 /pmc/articles/PMC6958650/ /pubmed/31976069 http://dx.doi.org/10.1177/2045125319899263 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Keshavarzi, Farinaz
Fox, Tony
Whiskey, Eromona
Taylor, David
Change in plasma concentration of clozapine and norclozapine following a switch of oral formulation
title Change in plasma concentration of clozapine and norclozapine following a switch of oral formulation
title_full Change in plasma concentration of clozapine and norclozapine following a switch of oral formulation
title_fullStr Change in plasma concentration of clozapine and norclozapine following a switch of oral formulation
title_full_unstemmed Change in plasma concentration of clozapine and norclozapine following a switch of oral formulation
title_short Change in plasma concentration of clozapine and norclozapine following a switch of oral formulation
title_sort change in plasma concentration of clozapine and norclozapine following a switch of oral formulation
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958650/
https://www.ncbi.nlm.nih.gov/pubmed/31976069
http://dx.doi.org/10.1177/2045125319899263
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