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Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure

BACKGROUND: Northern Senegal is a zone of very low malaria transmission, with an annual incidence of < 5/1000 inhabitants. This area, where the Senegal National Malaria Control Programme has initiated elimination activities, hosts Fulani, nomadic, pastoralists that spend the dry season in the sou...

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Autores principales: Seck, Mame Cheikh, Thwing, Julie, Badiane, Aida Sadikh, Rogier, Eric, Fall, Fatou Ba, Ndiaye, Pape Ibrahima, Diongue, Khadim, Mbow, Moustapha, Ndiaye, Mouhamadou, Diallo, Mamadou Alpha, Gomis, Jules François, Mbaye, Aminata, Ndiaye, Tolla, Gaye, Aminata, Sy, Mohamad, Déme, Awa Bineta, Ndiaye, Yaye Die, Ndiaye, Daouda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958760/
https://www.ncbi.nlm.nih.gov/pubmed/31931834
http://dx.doi.org/10.1186/s12936-020-3114-2
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author Seck, Mame Cheikh
Thwing, Julie
Badiane, Aida Sadikh
Rogier, Eric
Fall, Fatou Ba
Ndiaye, Pape Ibrahima
Diongue, Khadim
Mbow, Moustapha
Ndiaye, Mouhamadou
Diallo, Mamadou Alpha
Gomis, Jules François
Mbaye, Aminata
Ndiaye, Tolla
Gaye, Aminata
Sy, Mohamad
Déme, Awa Bineta
Ndiaye, Yaye Die
Ndiaye, Daouda
author_facet Seck, Mame Cheikh
Thwing, Julie
Badiane, Aida Sadikh
Rogier, Eric
Fall, Fatou Ba
Ndiaye, Pape Ibrahima
Diongue, Khadim
Mbow, Moustapha
Ndiaye, Mouhamadou
Diallo, Mamadou Alpha
Gomis, Jules François
Mbaye, Aminata
Ndiaye, Tolla
Gaye, Aminata
Sy, Mohamad
Déme, Awa Bineta
Ndiaye, Yaye Die
Ndiaye, Daouda
author_sort Seck, Mame Cheikh
collection PubMed
description BACKGROUND: Northern Senegal is a zone of very low malaria transmission, with an annual incidence of < 5/1000 inhabitants. This area, where the Senegal National Malaria Control Programme has initiated elimination activities, hosts Fulani, nomadic, pastoralists that spend the dry season in the south where malaria incidence is higher (150–450/1000 inhabitants) and return to the north with the first rains. Previous research demonstrated parasite prevalence of < 1% in this Fulani population upon return from the south, similar to that documented in the north in cross-sectional surveys. METHODS: A modified snowball sampling survey of nomadic pastoralists was conducted in five districts in northern Senegal during September and October 2014. Demographic information and dried blood spots were collected. Multiplex bead-based assays were used to assess antibody responses to merozoite surface protein (MSP-1(19)) antigen of the four primary Plasmodium species, as well as circumsporozoite protein (CSP) and liver stage antigen (LSA-1) of Plasmodium falciparum. RESULTS: In the five study districts, 1472 individuals were enrolled, with a median age of 22 years (range 1 to 80 years). Thirty-two percent of subjects were under 14 years and 57% were male. The overall seroprevalence of P. falciparum MSP-1(19), CSP and LSA-1 antibodies were 45, 12 and 5%, respectively. Plasmodium falciparum MSP-1(19) antibody responses increased significantly with age in all study areas, and were significantly higher among males. The highest seroprevalence to P. falciparum antigens was observed in the Kanel district (63%) and the lowest observed in Podor (28%). Low seroprevalence was observed for non-falciparum species in all the study sites: 0.4, 0.7 and 1.8%, respectively, for Plasmodium ovale, Plasmodium vivax and Plasmodium malariae MSP-1. Antibody responses to P. vivax were observed in all study sites except Kanel. CONCLUSION: Prevalence of P. falciparum MSP-1(19) antibodies and increases by study participant age provided data for low levels of exposure among this transient nomadic population. In addition, antibody responses to P. falciparum short half-life markers (CSP and LSA-1) and non-falciparum species were low. Further investigations are needed to understand the exposure of the Fulani population to P. vivax.
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spelling pubmed-69587602020-01-17 Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure Seck, Mame Cheikh Thwing, Julie Badiane, Aida Sadikh Rogier, Eric Fall, Fatou Ba Ndiaye, Pape Ibrahima Diongue, Khadim Mbow, Moustapha Ndiaye, Mouhamadou Diallo, Mamadou Alpha Gomis, Jules François Mbaye, Aminata Ndiaye, Tolla Gaye, Aminata Sy, Mohamad Déme, Awa Bineta Ndiaye, Yaye Die Ndiaye, Daouda Malar J Research BACKGROUND: Northern Senegal is a zone of very low malaria transmission, with an annual incidence of < 5/1000 inhabitants. This area, where the Senegal National Malaria Control Programme has initiated elimination activities, hosts Fulani, nomadic, pastoralists that spend the dry season in the south where malaria incidence is higher (150–450/1000 inhabitants) and return to the north with the first rains. Previous research demonstrated parasite prevalence of < 1% in this Fulani population upon return from the south, similar to that documented in the north in cross-sectional surveys. METHODS: A modified snowball sampling survey of nomadic pastoralists was conducted in five districts in northern Senegal during September and October 2014. Demographic information and dried blood spots were collected. Multiplex bead-based assays were used to assess antibody responses to merozoite surface protein (MSP-1(19)) antigen of the four primary Plasmodium species, as well as circumsporozoite protein (CSP) and liver stage antigen (LSA-1) of Plasmodium falciparum. RESULTS: In the five study districts, 1472 individuals were enrolled, with a median age of 22 years (range 1 to 80 years). Thirty-two percent of subjects were under 14 years and 57% were male. The overall seroprevalence of P. falciparum MSP-1(19), CSP and LSA-1 antibodies were 45, 12 and 5%, respectively. Plasmodium falciparum MSP-1(19) antibody responses increased significantly with age in all study areas, and were significantly higher among males. The highest seroprevalence to P. falciparum antigens was observed in the Kanel district (63%) and the lowest observed in Podor (28%). Low seroprevalence was observed for non-falciparum species in all the study sites: 0.4, 0.7 and 1.8%, respectively, for Plasmodium ovale, Plasmodium vivax and Plasmodium malariae MSP-1. Antibody responses to P. vivax were observed in all study sites except Kanel. CONCLUSION: Prevalence of P. falciparum MSP-1(19) antibodies and increases by study participant age provided data for low levels of exposure among this transient nomadic population. In addition, antibody responses to P. falciparum short half-life markers (CSP and LSA-1) and non-falciparum species were low. Further investigations are needed to understand the exposure of the Fulani population to P. vivax. BioMed Central 2020-01-13 /pmc/articles/PMC6958760/ /pubmed/31931834 http://dx.doi.org/10.1186/s12936-020-3114-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Seck, Mame Cheikh
Thwing, Julie
Badiane, Aida Sadikh
Rogier, Eric
Fall, Fatou Ba
Ndiaye, Pape Ibrahima
Diongue, Khadim
Mbow, Moustapha
Ndiaye, Mouhamadou
Diallo, Mamadou Alpha
Gomis, Jules François
Mbaye, Aminata
Ndiaye, Tolla
Gaye, Aminata
Sy, Mohamad
Déme, Awa Bineta
Ndiaye, Yaye Die
Ndiaye, Daouda
Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure
title Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure
title_full Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure
title_fullStr Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure
title_full_unstemmed Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure
title_short Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure
title_sort analysis of anti-plasmodium igg profiles among fulani nomadic pastoralists in northern senegal to assess malaria exposure
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958760/
https://www.ncbi.nlm.nih.gov/pubmed/31931834
http://dx.doi.org/10.1186/s12936-020-3114-2
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