Guidelines for cell-type heterogeneity quantification based on a comparative analysis of reference-free DNA methylation deconvolution software

BACKGROUND: Cell-type heterogeneity of tumors is a key factor in tumor progression and response to chemotherapy. Tumor cell-type heterogeneity, defined as the proportion of the various cell-types in a tumor, can be inferred from DNA methylation of surgical specimens. However, confounding factors kno...

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Detalles Bibliográficos
Autores principales: Decamps, Clémentine, Privé, Florian, Bacher, Raphael, Jost, Daniel, Waguet, Arthur, Houseman, Eugene Andres, Lurie, Eugene, Lutsik, Pavlo, Milosavljevic, Aleksandar, Scherer, Michael, Blum, Michael G. B., Richard, Magali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958785/
https://www.ncbi.nlm.nih.gov/pubmed/31931698
http://dx.doi.org/10.1186/s12859-019-3307-2

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