Cargando…
Stem cell therapy in critical limb ischemia: Current scenario and future trends
Critical limb ischemia (CLI) represents the most severe manifestation of peripheral arterial disease (PAD). It imposes a huge economic burden and is associated with high short-term mortality and adverse cardiovascular outcomes. Prompt recognition and early revascularization, surgical or endovascular...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958876/ https://www.ncbi.nlm.nih.gov/pubmed/31949342 http://dx.doi.org/10.4103/ijri.IJRI_385_19 |
_version_ | 1783487494202851328 |
---|---|
author | Sharma, Arun Sinha, Mumun Pandey, Niraj Nirmal Chandrashekhara, S H |
author_facet | Sharma, Arun Sinha, Mumun Pandey, Niraj Nirmal Chandrashekhara, S H |
author_sort | Sharma, Arun |
collection | PubMed |
description | Critical limb ischemia (CLI) represents the most severe manifestation of peripheral arterial disease (PAD). It imposes a huge economic burden and is associated with high short-term mortality and adverse cardiovascular outcomes. Prompt recognition and early revascularization, surgical or endovascular, with the aim of improving the inline bloodflow to the ischemic limb, are currently the standard of care. However, this strategy may not always be feasible or effective; hence, evaluation of newer pharmacological or angiogenic therapies for alleviating the symptoms of this alarming condition is of utmost importance. Cell-based therapies have shown promise in smaller studies; however, large-scale studies, demonstrating definite survival benefits, are entailed to ascertain their role in the management of CLI. |
format | Online Article Text |
id | pubmed-6958876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-69588762020-01-16 Stem cell therapy in critical limb ischemia: Current scenario and future trends Sharma, Arun Sinha, Mumun Pandey, Niraj Nirmal Chandrashekhara, S H Indian J Radiol Imaging Interventional Radiology Critical limb ischemia (CLI) represents the most severe manifestation of peripheral arterial disease (PAD). It imposes a huge economic burden and is associated with high short-term mortality and adverse cardiovascular outcomes. Prompt recognition and early revascularization, surgical or endovascular, with the aim of improving the inline bloodflow to the ischemic limb, are currently the standard of care. However, this strategy may not always be feasible or effective; hence, evaluation of newer pharmacological or angiogenic therapies for alleviating the symptoms of this alarming condition is of utmost importance. Cell-based therapies have shown promise in smaller studies; however, large-scale studies, demonstrating definite survival benefits, are entailed to ascertain their role in the management of CLI. Wolters Kluwer - Medknow 2019 2019-12-31 /pmc/articles/PMC6958876/ /pubmed/31949342 http://dx.doi.org/10.4103/ijri.IJRI_385_19 Text en Copyright: © 2019 Indian Journal of Radiology and Imaging http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Interventional Radiology Sharma, Arun Sinha, Mumun Pandey, Niraj Nirmal Chandrashekhara, S H Stem cell therapy in critical limb ischemia: Current scenario and future trends |
title | Stem cell therapy in critical limb ischemia: Current scenario and future trends |
title_full | Stem cell therapy in critical limb ischemia: Current scenario and future trends |
title_fullStr | Stem cell therapy in critical limb ischemia: Current scenario and future trends |
title_full_unstemmed | Stem cell therapy in critical limb ischemia: Current scenario and future trends |
title_short | Stem cell therapy in critical limb ischemia: Current scenario and future trends |
title_sort | stem cell therapy in critical limb ischemia: current scenario and future trends |
topic | Interventional Radiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958876/ https://www.ncbi.nlm.nih.gov/pubmed/31949342 http://dx.doi.org/10.4103/ijri.IJRI_385_19 |
work_keys_str_mv | AT sharmaarun stemcelltherapyincriticallimbischemiacurrentscenarioandfuturetrends AT sinhamumun stemcelltherapyincriticallimbischemiacurrentscenarioandfuturetrends AT pandeynirajnirmal stemcelltherapyincriticallimbischemiacurrentscenarioandfuturetrends AT chandrashekharash stemcelltherapyincriticallimbischemiacurrentscenarioandfuturetrends |