An Unusual Presentation of Richter's Transformation of Chronic Lymphocytic Leukemia in Liver and Lung on (18)F-Labeled Fluoro-2-Deoxyglucose Positron Emission Tomography/Computed Tomography

Richter's transformation (RT) is a rare complication of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) with unfavorable prognosis. The clinical and laboratory findings of RT are nonspecific and requires histopathological confirmation for the diagnosis. (18)F-labeled fluo...

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Autores principales: Sood, Apurva, Parihar, Ashwin Singh, Lad, Deepesh, Kumar, Rajender, Singh, Harmandeep, Mittal, Bhagwant Rai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Interesting Image
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958950/
https://www.ncbi.nlm.nih.gov/pubmed/31949376
http://dx.doi.org/10.4103/ijnm.IJNM_175_19
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author Sood, Apurva
Parihar, Ashwin Singh
Lad, Deepesh
Kumar, Rajender
Singh, Harmandeep
Mittal, Bhagwant Rai
author_facet Sood, Apurva
Parihar, Ashwin Singh
Lad, Deepesh
Kumar, Rajender
Singh, Harmandeep
Mittal, Bhagwant Rai
author_sort Sood, Apurva
collection PubMed
description Richter's transformation (RT) is a rare complication of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) with unfavorable prognosis. The clinical and laboratory findings of RT are nonspecific and requires histopathological confirmation for the diagnosis. (18)F-labeled fluoro-2-deoxyglucose positron-emission tomography/computed tomography ((18)F-FDG PET/CT) has shown higher diagnostic values for the detection of transformation of CLL/SLL to aggressive lymphoma. We present a case of CLL in remission for 6 years presenting with clinical features suggestive of RT. (18)F-FDG PET/CT done in our case showed liver and lung involvement with no lymphadenopathy, which is an unusual presentation of RT.
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spelling pubmed-69589502020-01-16 An Unusual Presentation of Richter's Transformation of Chronic Lymphocytic Leukemia in Liver and Lung on (18)F-Labeled Fluoro-2-Deoxyglucose Positron Emission Tomography/Computed Tomography Sood, Apurva Parihar, Ashwin Singh Lad, Deepesh Kumar, Rajender Singh, Harmandeep Mittal, Bhagwant Rai Indian J Nucl Med Interesting Image Richter's transformation (RT) is a rare complication of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) with unfavorable prognosis. The clinical and laboratory findings of RT are nonspecific and requires histopathological confirmation for the diagnosis. (18)F-labeled fluoro-2-deoxyglucose positron-emission tomography/computed tomography ((18)F-FDG PET/CT) has shown higher diagnostic values for the detection of transformation of CLL/SLL to aggressive lymphoma. We present a case of CLL in remission for 6 years presenting with clinical features suggestive of RT. (18)F-FDG PET/CT done in our case showed liver and lung involvement with no lymphadenopathy, which is an unusual presentation of RT. Wolters Kluwer - Medknow 2020 2019-12-31 /pmc/articles/PMC6958950/ /pubmed/31949376 http://dx.doi.org/10.4103/ijnm.IJNM_175_19 Text en Copyright: © 2019 Indian Journal of Nuclear Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Interesting Image
Sood, Apurva
Parihar, Ashwin Singh
Lad, Deepesh
Kumar, Rajender
Singh, Harmandeep
Mittal, Bhagwant Rai
An Unusual Presentation of Richter's Transformation of Chronic Lymphocytic Leukemia in Liver and Lung on (18)F-Labeled Fluoro-2-Deoxyglucose Positron Emission Tomography/Computed Tomography
title An Unusual Presentation of Richter's Transformation of Chronic Lymphocytic Leukemia in Liver and Lung on (18)F-Labeled Fluoro-2-Deoxyglucose Positron Emission Tomography/Computed Tomography
title_full An Unusual Presentation of Richter's Transformation of Chronic Lymphocytic Leukemia in Liver and Lung on (18)F-Labeled Fluoro-2-Deoxyglucose Positron Emission Tomography/Computed Tomography
title_fullStr An Unusual Presentation of Richter's Transformation of Chronic Lymphocytic Leukemia in Liver and Lung on (18)F-Labeled Fluoro-2-Deoxyglucose Positron Emission Tomography/Computed Tomography
title_full_unstemmed An Unusual Presentation of Richter's Transformation of Chronic Lymphocytic Leukemia in Liver and Lung on (18)F-Labeled Fluoro-2-Deoxyglucose Positron Emission Tomography/Computed Tomography
title_short An Unusual Presentation of Richter's Transformation of Chronic Lymphocytic Leukemia in Liver and Lung on (18)F-Labeled Fluoro-2-Deoxyglucose Positron Emission Tomography/Computed Tomography
title_sort unusual presentation of richter's transformation of chronic lymphocytic leukemia in liver and lung on (18)f-labeled fluoro-2-deoxyglucose positron emission tomography/computed tomography
topic Interesting Image
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958950/
https://www.ncbi.nlm.nih.gov/pubmed/31949376
http://dx.doi.org/10.4103/ijnm.IJNM_175_19
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