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LNC00673 suppresses proliferation and metastasis of pancreatic cancer via target miR-504/ HNF1A
Pancreatic cancer is a highly invasive malignant tumor of the digestive system. To explore the mechanism of pancreatic cancer development, development, invasion and metastasis, in this study we focused on long non-coding RNA (LncRNA), which has been reported to be involved in tumorigenesis. We ident...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959011/ https://www.ncbi.nlm.nih.gov/pubmed/31949497 http://dx.doi.org/10.7150/jca.32855 |
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author | Gong, Yi Dai, Hai-su Shu, Jun-jie Liu, Wei Bie, Ping Zhang, Lei-da |
author_facet | Gong, Yi Dai, Hai-su Shu, Jun-jie Liu, Wei Bie, Ping Zhang, Lei-da |
author_sort | Gong, Yi |
collection | PubMed |
description | Pancreatic cancer is a highly invasive malignant tumor of the digestive system. To explore the mechanism of pancreatic cancer development, development, invasion and metastasis, in this study we focused on long non-coding RNA (LncRNA), which has been reported to be involved in tumorigenesis. We identified a LINC00673, which is highly correlated with the pancreatic cancer risk. LINC00673 Overexpression is associated with good survival in pancreatic cancer patients, Effects of LINC00673 on pancreatic cancer cell apoptosis, viability, migration. LINC00673 negatively correlated with miR-504 and MiR-504 overexpression promoted cancer progression in Pancreatic cancer. MiR-504 negatively correlated with HNF1A, which was highly expressed Pancreatic cancer. HNF1A inhibited cell progression in pancreatic cancer cells. LINC00673 overexpression inhibited caner progression in nude mice. Taken together, LINC00673 can through suppress miR-504/ HNF1A regulating invasion and migration in pancreatic cancer. Also, we identified miR-504 as a target of LINC00673 in pancreatic cancer and LINC00673 can be used as a novel therapeutic target for the pancreatic cancer. |
format | Online Article Text |
id | pubmed-6959011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-69590112020-01-16 LNC00673 suppresses proliferation and metastasis of pancreatic cancer via target miR-504/ HNF1A Gong, Yi Dai, Hai-su Shu, Jun-jie Liu, Wei Bie, Ping Zhang, Lei-da J Cancer Research Paper Pancreatic cancer is a highly invasive malignant tumor of the digestive system. To explore the mechanism of pancreatic cancer development, development, invasion and metastasis, in this study we focused on long non-coding RNA (LncRNA), which has been reported to be involved in tumorigenesis. We identified a LINC00673, which is highly correlated with the pancreatic cancer risk. LINC00673 Overexpression is associated with good survival in pancreatic cancer patients, Effects of LINC00673 on pancreatic cancer cell apoptosis, viability, migration. LINC00673 negatively correlated with miR-504 and MiR-504 overexpression promoted cancer progression in Pancreatic cancer. MiR-504 negatively correlated with HNF1A, which was highly expressed Pancreatic cancer. HNF1A inhibited cell progression in pancreatic cancer cells. LINC00673 overexpression inhibited caner progression in nude mice. Taken together, LINC00673 can through suppress miR-504/ HNF1A regulating invasion and migration in pancreatic cancer. Also, we identified miR-504 as a target of LINC00673 in pancreatic cancer and LINC00673 can be used as a novel therapeutic target for the pancreatic cancer. Ivyspring International Publisher 2020-01-01 /pmc/articles/PMC6959011/ /pubmed/31949497 http://dx.doi.org/10.7150/jca.32855 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Gong, Yi Dai, Hai-su Shu, Jun-jie Liu, Wei Bie, Ping Zhang, Lei-da LNC00673 suppresses proliferation and metastasis of pancreatic cancer via target miR-504/ HNF1A |
title | LNC00673 suppresses proliferation and metastasis of pancreatic cancer via target miR-504/ HNF1A |
title_full | LNC00673 suppresses proliferation and metastasis of pancreatic cancer via target miR-504/ HNF1A |
title_fullStr | LNC00673 suppresses proliferation and metastasis of pancreatic cancer via target miR-504/ HNF1A |
title_full_unstemmed | LNC00673 suppresses proliferation and metastasis of pancreatic cancer via target miR-504/ HNF1A |
title_short | LNC00673 suppresses proliferation and metastasis of pancreatic cancer via target miR-504/ HNF1A |
title_sort | lnc00673 suppresses proliferation and metastasis of pancreatic cancer via target mir-504/ hnf1a |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959011/ https://www.ncbi.nlm.nih.gov/pubmed/31949497 http://dx.doi.org/10.7150/jca.32855 |
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