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Pyruvate dehydrogenase kinase 1 interferes with glucose metabolism reprogramming and mitochondrial quality control to aggravate stress damage in cancer

Pyruvate dehydrogenase kinase 1 (PDK1) is a key factor in the connection between glycolysis and the tricarboxylic acid cycle. Restoring the mitochondrial OXPHOS function by inhibiting glycolysis through targeting PDK1 has become a hot spot for tumor therapy. However, the specific mechanism by which...

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Detalles Bibliográficos
Autores principales:	Deng, Xinyue, Wang, Quan, Cheng, Meiyu, Chen, Yingying, Yan, Xiaoyu, Guo, Rui, Sun, Liankun, Li, Yang, Liu, Yanan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959030/ https://www.ncbi.nlm.nih.gov/pubmed/31949499 http://dx.doi.org/10.7150/jca.34330

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