Antitumor functions and mechanisms of nitidine chloride in human cancers

Nitidine chloride (NC), a quaternary ammonium alkaloid, exhibits multiple biological activities, including antimalarial, antifungal, and antiangiogenesis. Recently, NC has been characterized to perform antitumor activity in a variety of malignancies. NC has been identified to suppress cell prolifera...

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Autores principales: Cui, Yue, Wu, Linhui, Cao, Ruoxue, Xu, Hui, Xia, Jun, Wang, Z Peter, Ma, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959075/
https://www.ncbi.nlm.nih.gov/pubmed/31956371
http://dx.doi.org/10.7150/jca.37890
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author Cui, Yue
Wu, Linhui
Cao, Ruoxue
Xu, Hui
Xia, Jun
Wang, Z Peter
Ma, Jia
author_facet Cui, Yue
Wu, Linhui
Cao, Ruoxue
Xu, Hui
Xia, Jun
Wang, Z Peter
Ma, Jia
author_sort Cui, Yue
collection PubMed
description Nitidine chloride (NC), a quaternary ammonium alkaloid, exhibits multiple biological activities, including antimalarial, antifungal, and antiangiogenesis. Recently, NC has been characterized to perform antitumor activity in a variety of malignancies. NC has been identified to suppress cell proliferation, stimulate apoptosis, and induce cell cycle arrest, retard migration, invasion and metastasis. Moreover, NC is reported to sensitize cancer cells to chemotherapeutic drugs. In this review article, we describe the functions of NC in human cancers and discuss the molecular insight into NC-involved antitumor feature. This review article will stimulate the deeper investigation for using NC as a potent agent for the management of cancer patients.
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spelling pubmed-69590752020-01-18 Antitumor functions and mechanisms of nitidine chloride in human cancers Cui, Yue Wu, Linhui Cao, Ruoxue Xu, Hui Xia, Jun Wang, Z Peter Ma, Jia J Cancer Review Nitidine chloride (NC), a quaternary ammonium alkaloid, exhibits multiple biological activities, including antimalarial, antifungal, and antiangiogenesis. Recently, NC has been characterized to perform antitumor activity in a variety of malignancies. NC has been identified to suppress cell proliferation, stimulate apoptosis, and induce cell cycle arrest, retard migration, invasion and metastasis. Moreover, NC is reported to sensitize cancer cells to chemotherapeutic drugs. In this review article, we describe the functions of NC in human cancers and discuss the molecular insight into NC-involved antitumor feature. This review article will stimulate the deeper investigation for using NC as a potent agent for the management of cancer patients. Ivyspring International Publisher 2020-01-01 /pmc/articles/PMC6959075/ /pubmed/31956371 http://dx.doi.org/10.7150/jca.37890 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Cui, Yue
Wu, Linhui
Cao, Ruoxue
Xu, Hui
Xia, Jun
Wang, Z Peter
Ma, Jia
Antitumor functions and mechanisms of nitidine chloride in human cancers
title Antitumor functions and mechanisms of nitidine chloride in human cancers
title_full Antitumor functions and mechanisms of nitidine chloride in human cancers
title_fullStr Antitumor functions and mechanisms of nitidine chloride in human cancers
title_full_unstemmed Antitumor functions and mechanisms of nitidine chloride in human cancers
title_short Antitumor functions and mechanisms of nitidine chloride in human cancers
title_sort antitumor functions and mechanisms of nitidine chloride in human cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959075/
https://www.ncbi.nlm.nih.gov/pubmed/31956371
http://dx.doi.org/10.7150/jca.37890
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