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Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation

Background: The Matrix metalloproteinase-14 (MMP-14) expression has been shown to be overexpressed in different cancers. However, there is no comprehensive quantitative evaluation of the MMP-14 prognostic value in digestive system carcinoma (DSC). The aim of this study is to explore the correlation...

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Autores principales: Duan, Fujiao, Peng, Zhen, Yin, Jingjing, Yang, Zhongyu, Shang, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959085/
https://www.ncbi.nlm.nih.gov/pubmed/31956360
http://dx.doi.org/10.7150/jca.36469
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author Duan, Fujiao
Peng, Zhen
Yin, Jingjing
Yang, Zhongyu
Shang, Jia
author_facet Duan, Fujiao
Peng, Zhen
Yin, Jingjing
Yang, Zhongyu
Shang, Jia
author_sort Duan, Fujiao
collection PubMed
description Background: The Matrix metalloproteinase-14 (MMP-14) expression has been shown to be overexpressed in different cancers. However, there is no comprehensive quantitative evaluation of the MMP-14 prognostic value in digestive system carcinoma (DSC). The aim of this study is to explore the correlation between the MMP-14 expression and DSC prognosis. Methods: We conducted a meta-analysis to estimate the association strength between MMP-14 expression and prognosis. GEPIA and Kaplan Meier plotters were used to assess overall survival (OS), disease-free survival (DFS)/progression-free survival (PFS) in DSC patients and the differential expression of MMP-14 in DSC tissues and adjacent tissues. Results: A total of 20 studies including 2,519 patients with OS and 438 patients with DFS/PFS data were analyzed in evidence synthesis. Overall, the combined hazard ratio (HR) with 95% confidence interval (95% CI) was 1.98 (95%Cl: 1.77-2.22, P<0.001) for OS and 3.61 (95%Cl: 2.39-5.43, P<0.001) for DFS/PFS. For subgroup analyses, significant correlations were revealed between increased MMP-14 expression and poor OS in patients with gastric cancer (HR=2.21, 95%CI: 1.76-2.77, P<0.001), esophageal carcinoma (HR=2.01, 95%CI: 1.58-2.57, P<0.001), oral cancer (HR = 1.69, 95% CI: 1.30-2.20, P < 0.001) (HR=2.14, 95%CI 1.35-2.19, P<0.001) and hepatocarcinoma. In database verification analyses, the MMP-14 expression levels in normal tissues were significantly higher than that in DSC tissues, and significant associations were observed between high MMP-14 expression levels and poor prognosis. Conclusions: The high expression levels of MMP-14 might predict poor prognosis in DSC. Larger prospective clinical cohort studies are required to validate the prognostic role.
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spelling pubmed-69590852020-01-18 Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation Duan, Fujiao Peng, Zhen Yin, Jingjing Yang, Zhongyu Shang, Jia J Cancer Research Paper Background: The Matrix metalloproteinase-14 (MMP-14) expression has been shown to be overexpressed in different cancers. However, there is no comprehensive quantitative evaluation of the MMP-14 prognostic value in digestive system carcinoma (DSC). The aim of this study is to explore the correlation between the MMP-14 expression and DSC prognosis. Methods: We conducted a meta-analysis to estimate the association strength between MMP-14 expression and prognosis. GEPIA and Kaplan Meier plotters were used to assess overall survival (OS), disease-free survival (DFS)/progression-free survival (PFS) in DSC patients and the differential expression of MMP-14 in DSC tissues and adjacent tissues. Results: A total of 20 studies including 2,519 patients with OS and 438 patients with DFS/PFS data were analyzed in evidence synthesis. Overall, the combined hazard ratio (HR) with 95% confidence interval (95% CI) was 1.98 (95%Cl: 1.77-2.22, P<0.001) for OS and 3.61 (95%Cl: 2.39-5.43, P<0.001) for DFS/PFS. For subgroup analyses, significant correlations were revealed between increased MMP-14 expression and poor OS in patients with gastric cancer (HR=2.21, 95%CI: 1.76-2.77, P<0.001), esophageal carcinoma (HR=2.01, 95%CI: 1.58-2.57, P<0.001), oral cancer (HR = 1.69, 95% CI: 1.30-2.20, P < 0.001) (HR=2.14, 95%CI 1.35-2.19, P<0.001) and hepatocarcinoma. In database verification analyses, the MMP-14 expression levels in normal tissues were significantly higher than that in DSC tissues, and significant associations were observed between high MMP-14 expression levels and poor prognosis. Conclusions: The high expression levels of MMP-14 might predict poor prognosis in DSC. Larger prospective clinical cohort studies are required to validate the prognostic role. Ivyspring International Publisher 2020-01-01 /pmc/articles/PMC6959085/ /pubmed/31956360 http://dx.doi.org/10.7150/jca.36469 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Duan, Fujiao
Peng, Zhen
Yin, Jingjing
Yang, Zhongyu
Shang, Jia
Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation
title Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation
title_full Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation
title_fullStr Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation
title_full_unstemmed Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation
title_short Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation
title_sort expression of mmp-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959085/
https://www.ncbi.nlm.nih.gov/pubmed/31956360
http://dx.doi.org/10.7150/jca.36469
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