A Case of Salazosulfapyridine-Induced Hypersensitivity Syndrome in a Rheumatoid Arthritis Patient with Relapse of Skin Erythema

We experienced a rare case of drug-induced hypersensitivity syndrome (DIHS) in which salazosulfapyridine (SASP) reactivated human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV), which resulted in a relapse of skin symptoms after changing to mizoribine. At the time of recurrence of skin erythema aft...

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Autores principales: Itoi-Ochi, Saori, Nakagawa, Yukinobu, Tanemura, Atsushi, Hirao, Makoto, Fujimoto, Manabu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2019
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959106/
https://www.ncbi.nlm.nih.gov/pubmed/31966030
http://dx.doi.org/10.1159/000504644
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author Itoi-Ochi, Saori
Nakagawa, Yukinobu
Tanemura, Atsushi
Hirao, Makoto
Fujimoto, Manabu
author_facet Itoi-Ochi, Saori
Nakagawa, Yukinobu
Tanemura, Atsushi
Hirao, Makoto
Fujimoto, Manabu
author_sort Itoi-Ochi, Saori
collection PubMed
description We experienced a rare case of drug-induced hypersensitivity syndrome (DIHS) in which salazosulfapyridine (SASP) reactivated human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV), which resulted in a relapse of skin symptoms after changing to mizoribine. At the time of recurrence of skin erythema after the initiation of mizoribine, the serum DNA titers of not HHV-6 but CMV were elevated. A drug-induced lymphocyte stimulation test was negative for mizoribine but positive for SASP. In this case, DIHS developed with SASP in association with HHV-6 and CMV reactivation. The immunocompromised state induced by herpes virus reactivation and mizoribine might have caused the relapse of skin erythema.
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spelling pubmed-69591062020-01-21 A Case of Salazosulfapyridine-Induced Hypersensitivity Syndrome in a Rheumatoid Arthritis Patient with Relapse of Skin Erythema Itoi-Ochi, Saori Nakagawa, Yukinobu Tanemura, Atsushi Hirao, Makoto Fujimoto, Manabu Case Rep Dermatol Single Case We experienced a rare case of drug-induced hypersensitivity syndrome (DIHS) in which salazosulfapyridine (SASP) reactivated human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV), which resulted in a relapse of skin symptoms after changing to mizoribine. At the time of recurrence of skin erythema after the initiation of mizoribine, the serum DNA titers of not HHV-6 but CMV were elevated. A drug-induced lymphocyte stimulation test was negative for mizoribine but positive for SASP. In this case, DIHS developed with SASP in association with HHV-6 and CMV reactivation. The immunocompromised state induced by herpes virus reactivation and mizoribine might have caused the relapse of skin erythema. S. Karger AG 2019-12-17 /pmc/articles/PMC6959106/ /pubmed/31966030 http://dx.doi.org/10.1159/000504644 Text en Copyright © 2019 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Itoi-Ochi, Saori
Nakagawa, Yukinobu
Tanemura, Atsushi
Hirao, Makoto
Fujimoto, Manabu
A Case of Salazosulfapyridine-Induced Hypersensitivity Syndrome in a Rheumatoid Arthritis Patient with Relapse of Skin Erythema
title A Case of Salazosulfapyridine-Induced Hypersensitivity Syndrome in a Rheumatoid Arthritis Patient with Relapse of Skin Erythema
title_full A Case of Salazosulfapyridine-Induced Hypersensitivity Syndrome in a Rheumatoid Arthritis Patient with Relapse of Skin Erythema
title_fullStr A Case of Salazosulfapyridine-Induced Hypersensitivity Syndrome in a Rheumatoid Arthritis Patient with Relapse of Skin Erythema
title_full_unstemmed A Case of Salazosulfapyridine-Induced Hypersensitivity Syndrome in a Rheumatoid Arthritis Patient with Relapse of Skin Erythema
title_short A Case of Salazosulfapyridine-Induced Hypersensitivity Syndrome in a Rheumatoid Arthritis Patient with Relapse of Skin Erythema
title_sort case of salazosulfapyridine-induced hypersensitivity syndrome in a rheumatoid arthritis patient with relapse of skin erythema
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959106/
https://www.ncbi.nlm.nih.gov/pubmed/31966030
http://dx.doi.org/10.1159/000504644
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