Non-genotoxic MDM2 inhibition selectively induces a pro-apoptotic p53 gene signature in chronic lymphocytic leukemia cells

Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous hematologic malignancy. In approximately 90% of cases the TP53 gene is in its wildtype state at diagnosis of this malignancy. As mouse double-minute-2 homolog (MDM2) is a primary repressor of p53, targeting this protein is an attractiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Ciardullo, Carmela, Aptullahoglu, Erhan, Woodhouse, Laura, Lin, Wei-Yu, Wallis, Jonathan P, Marr, Helen, Marshall, Scott, Bown, Nick, Willmore, Elaine, Lunec, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959162/
https://www.ncbi.nlm.nih.gov/pubmed/31004033
http://dx.doi.org/10.3324/haematol.2018.206631

Ejemplares similares

Ejemplares similares