Functional interplay between NF-κB-inducing kinase and c-Abl kinases limits response to Aurora inhibitors in multiple myeloma

Considering that Aurora kinase inhibitors are currently under clinical investigation in hematologic cancers, the identification of molecular events that limit the response to such agents is essential for enhancing clinical outcomes. Here, we discover a NF-κB-inducing kinase (NIK)-c-Abl-STAT3 signali...

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Detalles Bibliográficos
Autores principales: Mazzera, Laura, Abeltino, Manuela, Lombardi, Guerino, Cantoni, Anna Maria, Ria, Roberto, Ricca, Micaela, Saltarella, Ilaria, Naponelli, Valeria, Rizzi, Federica Maria Angela, Perris, Roberto, Corradi, Attilio, Vacca, Angelo, Bonati, Antonio, Lunghi, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959191/
https://www.ncbi.nlm.nih.gov/pubmed/30948493
http://dx.doi.org/10.3324/haematol.2018.208280

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