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Novel evidence for a greater burden of ambient air pollution on cardiovascular disease
Ambient and household air pollution is a major health problem worldwide, contributing annually to approximately seven million of all-cause avoidable deaths, shorter life expectancy, and significant direct and indirect costs for the community. Air pollution is a complex mixture of gaseous and particu...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ferrata Storti Foundation
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959193/ https://www.ncbi.nlm.nih.gov/pubmed/31672903 http://dx.doi.org/10.3324/haematol.2019.225086 |
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author | Mannucci, Pier Mannuccio Harari, Sergio Franchini, Massimo |
author_facet | Mannucci, Pier Mannuccio Harari, Sergio Franchini, Massimo |
author_sort | Mannucci, Pier Mannuccio |
collection | PubMed |
description | Ambient and household air pollution is a major health problem worldwide, contributing annually to approximately seven million of all-cause avoidable deaths, shorter life expectancy, and significant direct and indirect costs for the community. Air pollution is a complex mixture of gaseous and particulate materials that vary depending on their source and physicochemical features. Each material has detrimental effects on human health, but a number of experimental and clinical studies have shown a strong impact for fine particulate matter (PM(2.5)). In particular, there is more and more evidence that PM(2.5) exerts adverse effects particularly on the cardiovascular system, contributing substantially (mainly through mechanisms of atherosclerosis, thrombosis and inflammation) to coronary artery and cerebrovascular disease, but also to heart failure, hypertension, diabetes and cardiac arrhythmias. In this review, we summarize knowledge on the mechanisms and magnitude of the cardiovascular adverse effects of short-and long-term exposure to ambient air pollution, particularly for the PM(2.5) size fraction. We also emphasize that very recent data indicate that the global mortality and morbidity burden of cardiovascular disease associated with this air pollutant is dramatically greater than what has been thought up to now. |
format | Online Article Text |
id | pubmed-6959193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Ferrata Storti Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-69591932020-01-22 Novel evidence for a greater burden of ambient air pollution on cardiovascular disease Mannucci, Pier Mannuccio Harari, Sergio Franchini, Massimo Haematologica Review Article Ambient and household air pollution is a major health problem worldwide, contributing annually to approximately seven million of all-cause avoidable deaths, shorter life expectancy, and significant direct and indirect costs for the community. Air pollution is a complex mixture of gaseous and particulate materials that vary depending on their source and physicochemical features. Each material has detrimental effects on human health, but a number of experimental and clinical studies have shown a strong impact for fine particulate matter (PM(2.5)). In particular, there is more and more evidence that PM(2.5) exerts adverse effects particularly on the cardiovascular system, contributing substantially (mainly through mechanisms of atherosclerosis, thrombosis and inflammation) to coronary artery and cerebrovascular disease, but also to heart failure, hypertension, diabetes and cardiac arrhythmias. In this review, we summarize knowledge on the mechanisms and magnitude of the cardiovascular adverse effects of short-and long-term exposure to ambient air pollution, particularly for the PM(2.5) size fraction. We also emphasize that very recent data indicate that the global mortality and morbidity burden of cardiovascular disease associated with this air pollutant is dramatically greater than what has been thought up to now. Ferrata Storti Foundation 2019-12 /pmc/articles/PMC6959193/ /pubmed/31672903 http://dx.doi.org/10.3324/haematol.2019.225086 Text en Copyright© 2019 Ferrata Storti Foundation Material published in Haematologica is covered by copyright. All rights are reserved to the Ferrata Storti Foundation. Use of published material is allowed under the following terms and conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode. Copies of published material are allowed for personal or internal use. Sharing published material for non-commercial purposes is subject to the following conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode, sect. 3. Reproducing and sharing published material for commercial purposes is not allowed without permission in writing from the publisher. |
spellingShingle | Review Article Mannucci, Pier Mannuccio Harari, Sergio Franchini, Massimo Novel evidence for a greater burden of ambient air pollution on cardiovascular disease |
title | Novel evidence for a greater burden of ambient air pollution on cardiovascular disease |
title_full | Novel evidence for a greater burden of ambient air pollution on cardiovascular disease |
title_fullStr | Novel evidence for a greater burden of ambient air pollution on cardiovascular disease |
title_full_unstemmed | Novel evidence for a greater burden of ambient air pollution on cardiovascular disease |
title_short | Novel evidence for a greater burden of ambient air pollution on cardiovascular disease |
title_sort | novel evidence for a greater burden of ambient air pollution on cardiovascular disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959193/ https://www.ncbi.nlm.nih.gov/pubmed/31672903 http://dx.doi.org/10.3324/haematol.2019.225086 |
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